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Frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women: a community based cohort study.

Aghaizu, A; Reid, F; Kerry, S; Hay, PE; Mallinson, H; Jensen, JS; Kerry, S; Kerry, S; Oakeshott, P (2014) Frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women: a community based cohort study. Sex Transm Infect, 90 (7). pp. 524-528. ISSN 1472-3263 https://doi.org/10.1136/sextrans-2014-051607
SGUL Authors: Hay, Phillip Edward Kerry, Sally Margaret Oakeshott, Philippa Reid, Fiona Dorothy Alexandra Kerry-Barnard, Sarah Ruth

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Abstract

OBJECTIVE: To investigate the frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women in the community. DESIGN: Cohort study. SETTING: 20 London universities and Further Education colleges. PARTICIPANTS: 954 sexually experienced women, mean age 21.5 years (range 16-27), 26% from ethnic minorities, who were recruited to the Prevention of Pelvic Infection (POPI) chlamydia screening trial between 2004 and 2006, and returned repeat postal self-taken vaginal swabs 11-32 (median 16) months after recruitment. RESULTS: The estimated annual incidence of chlamydia infection among 907 women who tested negative at baseline was 3.4 per 100 person-years (95% CI 2.5 to 4.6 per 100 person-years), but 6.6 per 100 person-years (95% CI 4.5 to 9.3 per 100 person-years) in the 326 teenagers (<20 years). Predictors of incident chlamydia infection were age <20 years (relative risk (RR) 4.0, 95% CI 2.1 to 7.5), and (after adjusting for age) a new sexual partner during 12 months follow-up (RR 4.4, 95% CI 2.0 to 9.9), smoking (RR 2.2 95% CI 1.2 to 3.9), concurrent bacterial vaginosis (RR 2.0 95% CI 1.1 to 3.9) and high risk carcinogenic human papillomavirus (RR 2.2, 95% CI 1.1 to 4.3). Of 47 women positive for chlamydia at baseline, 12 (25.5%, 95% CI 13.9% to 40.3%) had redetected infection at a median of 16 months follow-up. Taking into account follow-up time (65 person-years), the annual redetection rate was 18.5 per 100 person-years (95% CI 9.9 to 30.0 per 100 person-years). CONCLUSIONS: One in four women with chlamydia infection at baseline retested positive, supporting recent recommendations to routinely retest chlamydia positives.

Item Type: Article
Additional Information: This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
Keywords: Chlamydia Infection, Chlamydia Trachomatis, Public Health, Sexual Health, Testing, Adolescent, Adult, Age Factors, Chlamydia Infections, Chlamydia trachomatis, Cohort Studies, Ethnic Groups, Female, Humans, Incidence, London, Papillomavirus Infections, Recurrence, Risk Factors, Sexual Behavior, Sexual Partners, Smoking, Vaginosis, Bacterial, Young Adult, Humans, Chlamydia trachomatis, Chlamydia Infections, Vaginosis, Bacterial, Papillomavirus Infections, Recurrence, Incidence, Risk Factors, Cohort Studies, Smoking, Sexual Behavior, Age Factors, Adolescent, Adult, Ethnic Groups, Sexual Partners, London, Female, Young Adult, 1103 Clinical Sciences, 1117 Public Health And Health Services, 1108 Medical Microbiology, Public Health
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Sex Transm Infect
ISSN: 1472-3263
Language: eng
Dates:
DateEvent
November 2014Published
6 August 2014Published Online
5 July 2014Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
G0601669Medical Research CouncilUNSPECIFIED
80280Medical Research CouncilUNSPECIFIED
PubMed ID: 25100744
Web of Science ID: WOS:000344104100006
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107366
Publisher's version: https://doi.org/10.1136/sextrans-2014-051607

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