Zaph, C; Cooper, PJ; Harris, NL
(2014)
Mucosal immune responses following intestinal nematode infection.
Parasite Immunology, 36 (9).
pp. 439-452.
ISSN 1365-3024
https://doi.org/10.1111/pim.12090
SGUL Authors: Cooper, Philip John
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Abstract
In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years). Although these organisms have been eradicated to a large extent within westernized human populations, those living within rural areas of developing countries continue to suffer from high infection rates. Indeed, recent estimates indicate that approximately 2.5 billion people worldwide, mainly children, currently suffer from infection with intestinal helminths (also known as geohelminths and soil-transmitted helminths) . Paradoxically, the eradication of helminths is thought to contribute to the increased incidence of autoimmune diseases and allergy observed in developed countries. In this review, we will summarize our current understanding of host-helminth interactions at the mucosal surface that result in parasite expulsion or permit the establishment of chronic infections with luminal dwelling adult worms. We will also provide insight into the adaptive immune mechanisms that provide immune protection against re-infection with helminth larvae, a process that is likely to be key to the future development of successful vaccination strategies. Lastly, the contribution of helminths to immune modulation and particularly to the treatment of allergy and inflammatory bowel disease will be discussed.
Item Type: |
Article
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Additional Information: |
© 2013 The Authors. Parasite Immunology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
Keywords: |
geohelminth, immune-expulsion, intestinal helminth, mucosal immunity, nematode, type 2 immunity, Adaptive Immunity, Animals, Helminthiasis, Humans, Immunity, Mucosal, Intestinal Diseases, Nematode Infections, geohelminth, Mycology & Parasitology, 0605 Microbiology, 1108 Medical Microbiology, 0707 Veterinary Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Parasite Immunology |
ISSN: |
1365-3024 |
Language: |
eng |
Dates: |
Date | Event |
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September 2014 | Published |
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Projects: |
Project ID | Funder | Funder ID |
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88862/Z/09/Z | Wellcome Trust | UNSPECIFIED | UNSPECIFIED | Canadian Institutes of Health Research | UNSPECIFIED |
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PubMed ID: |
25201407 |
Web of Science ID: |
WOS:000341881900006 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/107346 |
Publisher's version: |
https://doi.org/10.1111/pim.12090 |
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