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Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling.

Femminella, GD; Barrese, V; Ferrara, N; Rengo, G (2014) Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. Pharmacogenomics and Personalized Medicine, 7. pp. 267-273. ISSN 1178-7066 https://doi.org/10.2147/PGPM.S49799
SGUL Authors: Barrese, Vincenzo

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Abstract

Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic differences. Pharmacogenomics is the study of genetic contributions to drug response variability in order to provide evidence for a tailored therapy in an individual patient. Several studies have investigated the pharmacogenomics of the adrenergic receptor system and its role in the context of the use of β-blockers in treating heart failure. In this review, we will focus on the most significant polymorphisms described in the literature involving adrenergic receptors and adrenergic receptor-related proteins, as well as genetic variations influencing β-blocker metabolism.

Item Type: Article
Additional Information: © 2014 Femminella et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php
Keywords: adrenergic system, functional recovery, polymorphisms, β-blockers, 1115 Pharmacology And Pharmaceutical Sciences, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Pharmacogenomics and Personalized Medicine
ISSN: 1178-7066
Language: eng
Dates:
DateEvent
9 September 2014Published
PubMed ID: 25276090
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107277
Publisher's version: https://doi.org/10.2147/PGPM.S49799

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