Lam, RY; Lin, ZX; Sviderskaya, EV; Cheng, CH
(2014)
Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions.
International Journal of Molecular Sciences, 15 (8).
pp. 14649-14668.
ISSN 1422-0067
https://doi.org/10.3390/ijms150814649
SGUL Authors: Sviderskaya, Elena Vladimirovna
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Abstract
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer. In our previous study, selected Chinese medicines traditionally used to treat hyperpigmentation were tested for anti-hyperpigmentary effects using a melan-a cell culture model. Among the tested chemical compounds, 4-ethylresorcinol, 4-ethylphenol and 1-tetradecanol were found to possess hypopigmentary effects. Western blot analysis, reverse transcriptase polymerase chain reaction (RT-PCR), cyclic adenosine monophosphate (cAMP) assay, protein kinase A (PKA) activity assay, tyrosinase inhibition assay and lipid peroxidation inhibition assay were performed to reveal the underlying cellular and molecular mechanisms of the hypopigmentary effects. 4-Ethylresorcinol and 4-ethylphenol attenuated mRNA and protein expression of tyrosinase-related protein (TRP)-2, and possessed antioxidative effect by inhibiting lipid peroxidation. 1-Tetradecanol was able to attenuate protein expression of tyrosinase. The hypopigmentary actions of 4-ethylresorcinol, 4-ethylphenol and 1-tetradecanol were associated with regulating downstream proteins along the PKA pathway. 4-Ethylresorcinol was more effective in inhibiting melanin synthesis when compared to 4-ethylphenol and 1-tetradecanol.
Item Type: |
Article
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Additional Information: |
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
Keywords: |
depigmenting agents, hyperpigmentation, melan-a, 4-ethylresorcinol, 4-ethylphenol, 1-tetradecanol, Chemical Physics, 0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS) |
Journal or Publication Title: |
International Journal of Molecular Sciences |
ISSN: |
1422-0067 |
Language: |
eng |
Dates: |
Date | Event |
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21 August 2014 | Published |
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PubMed ID: |
25196602 |
Web of Science ID: |
WOS:000341519600090 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/107261 |
Publisher's version: |
https://doi.org/10.3390/ijms150814649 |
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