Hegedus, A;
Nyamweya, S;
Zhang, Y;
Govind, S;
Aspinall, R;
Mashanova, A;
Jansen, VA;
Whittle, H;
Jaye, A;
Flanagan, KL;
et al.
Hegedus, A; Nyamweya, S; Zhang, Y; Govind, S; Aspinall, R; Mashanova, A; Jansen, VA; Whittle, H; Jaye, A; Flanagan, KL; Macallan, DC
(2014)
Protection Versus Pathology in Aviremic and High Viral Load HIV-2 Infection-The Pivotal Role of Immune Activation and T-cell Kinetics.
Journal of Infectious Diseases, 210 (5).
752 - 761.
ISSN 0022-1899
https://doi.org/10.1093/infdis/jiu165
SGUL Authors: Macallan, Derek Clive Zhang, Yan Nyamweya, Samuel
![[img]](https://openaccess.sgul.ac.uk/107174/1.hassmallThumbnailVersion/J%20Infect%20Dis.-2014-Hegedus-752-61.pdf) ![](https://openaccess.sgul.ac.uk/107174/1.haspreviewThumbnailVersion/J%20Infect%20Dis.-2014-Hegedus-752-61.pdf) Preview |
|
["document_typename_cannot open `/data/SGUL/sgul/eprints3/archives/sgul/documents/disk0/00/10/71/74/01/J' (No such file or directory)
cannot open `Infect' (No such file or directory)
cannot open `Dis.-2014-Hegedus-752-61.pdf' (No such file or directory)" not defined]
Published Version
Download (432kB)
| Preview
|
Abstract
Background. Many human immunodeficiency virus (HIV)–2-infected individuals remain aviremic and behave as long-term non-progressors but some progress to AIDS. We hypothesized that immune activation and T-cell turnover would be critical determinants of non-progressor/progressor status.
Methods. We studied 37 subjects in The Gambia, West Africa: 10 HIV-negative controls, 10 HIV-2-infected subjects with low viral loads (HIV-2-LV), 7 HIV-2-infected subjects with high viral loads (HIV-2-HV), and 10 with HIV-1 infection. We measured in vivo T-cell turnover using deuterium-glucose labeling, and correlated results with T-cell phenotype (by flow cytometry) and T-cell receptor excision circle (TREC) abundance.
Results. Immune activation (HLA-DR/CD38 coexpression) differed between groups with a significant trend: controls <HIV-2-LV <HIV-1 <HIV-2-HV (P < .01 for all cell types). A similar trend was observed in the pattern of in vivo turnover of memory CD4+ and CD8+ T-cells and TREC depletion in naive CD4+ T-cells, although naive T-cell turnover was relatively unaffected by either infection. T-cell turnover, immune activation, and progressor status were closely associated.
Conclusions. HIV-2 non-progressors have low rates of T-cell turnover (both CD4+ and CD8+) and minimal immune activation; high viral load HIV-2 progressors had high values, similar to or exceeding those in HIV-1 infection.
Item Type: |
Article
|
Additional Information: |
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
CD4, CD8, HIV pathogenesis, HIV-1, HIV-2, T-cell, immune activation, immune memory, Microbiology, 11 Medical And Health Sciences, 06 Biological Sciences |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Journal of Infectious Diseases |
ISSN: |
0022-1899 |
Related URLs: |
|
Dates: |
Date | Event |
---|
1 September 2014 | Published |
|
PubMed ID: |
24803534 |
Web of Science ID: |
24803534 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/107174 |
Publisher's version: |
https://doi.org/10.1093/infdis/jiu165 |
Statistics
Item downloaded times since 16 Sep 2014.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |