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Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates

Salter, SJ; Hinds, J; Gould, KA; Lambertsen, L; Hanage, WP; Antonio, M; Turner, P; Hermans, PW; Bootsma, HJ; O'Brien, KL; et al. Salter, SJ; Hinds, J; Gould, KA; Lambertsen, L; Hanage, WP; Antonio, M; Turner, P; Hermans, PW; Bootsma, HJ; O'Brien, KL; Bentley, SD (2012) Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates. MICROBIOLOGY-SGM, 158. 1560 - 1569. ISSN 1350-0872 https://doi.org/10.1099/mic.0.056580-0
SGUL Authors: Hinds, Jason

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Abstract

The capsule polysaccharide locus (cps) is the site of the capsule biosynthesis gene cluster in encapsulated Streptococcus pneumoniae. A set of pneumococcal samples and non-pneumococcal streptococci from Denmark, the Gambia, the Netherlands, Thailand, the UK and the USA were sequenced at the cps locus to elucidate serologically mistyped or non-typable isolates. We identified a novel serotype 33B/33C mosaic capsule cluster and previously unseen serotype 22F capsule genes, disrupted and deleted cps clusters, the presence of aliB and nspA genes that are unrelated to capsule production, and similar genes in the non-pneumococcal samples. These data provide greater understanding of diversity at a locus which is crucial to the antigenic diversity of the pathogen and current vaccine strategies.

Item Type: Article
Additional Information: Copyright 2012 SGM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Bacterial Capsules, Bacterial Proteins, Gene Deletion, Genetic Loci, Genetic Variation, Humans, Molecular Sequence Data, Multigene Family, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Science & Technology, Life Sciences & Biomedicine, Microbiology, MICROBIOLOGY, COAGGREGATION RECEPTOR POLYSACCHARIDES, SEROTYPE 19A, SEQUENCE ALIGNMENT, INVASIVE DISEASE, UNITED-STATES, PNEUMOCOCCI, IDENTIFICATION, POPULATION, DYNAMICS, CHILDREN, Microbiology, MD Multidisciplinary, Science & Technology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: MICROBIOLOGY-SGM
ISSN: 1350-0872
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Dates:
DateEvent
1 June 2012Published
Web of Science ID: WOS:000306500700018
URI: https://openaccess.sgul.ac.uk/id/eprint/107147
Publisher's version: https://doi.org/10.1099/mic.0.056580-0

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