Nibali, L; Henderson, B; Sadiq, ST; Donos, N
(2014)
Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases.
Journal of Oral Microbiology, 6 (22962).
ISSN 2000-2297
https://doi.org/10.3402/jom.v6.22962
SGUL Authors: Sadiq, Syed Tariq
![[img]](https://openaccess.sgul.ac.uk/107090/1.hassmallThumbnailVersion/JOM-6-22962.pdf) ![](https://openaccess.sgul.ac.uk/107090/1.haspreviewThumbnailVersion/JOM-6-22962.pdf) Preview |
|
["document_typename_application/pdf; charset=binary" not defined]
Published Version
Available under License St George's repository terms & conditions.
Download (465kB)
| Preview
|
Abstract
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining the composition of human microbial biofilms and the response to this microbial challenge. We hereby introduce the term 'genetic dysbiosis' to highlight the role of human genetic variants affecting microbial recognition and host response in creating an environment conducive to changes in the normal microbiota. Such changes can, in turn, predispose to, and influence, diseases such as: cancer, inflammatory bowel disease, rheumatoid arthritis, psoriasis, bacterial vaginosis and periodontitis. This review presents the state of the evidence on host genetic factors affecting dysbiosis and microbial misrecognition (i.e. an aberrant response to the normal microbiota) and highlights the need for further research in this area.
Item Type: |
Article
|
Additional Information: |
Copyright: 2014 Luigi Nibali et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: |
dysbiosis, genetic, inflammation, microbiome, dysbiosis, genetic, inflammation, microbiome |
SGUL Research Institute / Research Centre: |
Academic Structure > Infection and Immunity Research Institute (INII) |
Journal or Publication Title: |
Journal of Oral Microbiology |
ISSN: |
2000-2297 |
Related URLs: |
|
Dates: |
Date | Event |
---|
25 February 2014 | Published |
|
PubMed ID: |
24578801 |
Web of Science ID: |
24578801 |
![](http://static.pubmed.gov/portal/portal3rc.fcgi/2745237/img/27842) |
Go to PubMed abstract |
URI: |
https://openaccess.sgul.ac.uk/id/eprint/107090 |
Publisher's version: |
https://doi.org/10.3402/jom.v6.22962 |
Statistics
Item downloaded times since 29 Sep 2014.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |