SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

How early can myocardial iron overload occur in Beta thalassemia major?

Yang, G; Liu, R; Peng, P; Long, L; Zhang, X; Yang, W; Tan, S; Pan, H; Long, X; He, T; et al. Yang, G; Liu, R; Peng, P; Long, L; Zhang, X; Yang, W; Tan, S; Pan, H; Long, X; He, T; Anderson, L; Lai, Y (2014) How early can myocardial iron overload occur in Beta thalassemia major? PLOS ONE, 9 (1). e85379. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0085379
SGUL Authors: He, Taigang

[img]
Preview
["document_typename_application/pdf; charset=binary" not defined] Published Version
Download (1MB) | Preview

Abstract

BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM. METHODS AND RESULTS: We analyzed T2* cardiac magnetic resonance (CMR), left ventricular ejection fraction (LVEF) and serum ferritin (SF) in 201 beta TM patients. The median age was 9 years old. Patients received an average of 13 units of blood per year. The median SF level was 4536 ng/ml and 165 patients (82.1%) had SF>2500 ng/ml. Myocardial iron overload was detected in 68 patients (33.8%) and severe myocardial iron overload was detected in 26 patients (12.6%). Twenty-two patients ≤10 years old had myocardial iron overload, three of whom were only 6 years old. No myocardial iron overload was detected under the age of 6 years. Median LVEF was 64% (measured by CMR in 175 patients). Five of 6 patients with a LVEF<56% and 8 of 10 patients with cardiac disease had myocardial iron overload. CONCLUSIONS: The TM patients under follow-up at this regional centre in China patients are younger than other reported cohorts, more poorly-chelated, and have a high burden of iron overload. Myocardial siderosis occurred in patients younger than previously reported, and was strongly associated with impaired LVEF and cardiac disease. For such poorly-chelated TM patients, our data shows that the first assessment of cardiac T2* should be performed as early as 6 years old.

Item Type: Article
Additional Information: PMCID: PMC3899006 ©2014 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: PLOS ONE
ISSN: 1932-6203
Related URLs:
Dates:
DateEvent
22 January 2014Published
PubMed ID: 24465548
Web of Science ID: 24465548
Download EPMC Full text (PDF)
Download EPMC Full text (HTML)
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/104829
Publisher's version: https://doi.org/10.1371/journal.pone.0085379

Actions (login required)

Edit Item Edit Item