Yang, G;
Liu, R;
Peng, P;
Long, L;
Zhang, X;
Yang, W;
Tan, S;
Pan, H;
Long, X;
He, T;
et al.
Yang, G; Liu, R; Peng, P; Long, L; Zhang, X; Yang, W; Tan, S; Pan, H; Long, X; He, T; Anderson, L; Lai, Y
(2014)
How early can myocardial iron overload occur in Beta thalassemia major?
PLOS ONE, 9 (1).
e85379.
ISSN 1932-6203
https://doi.org/10.1371/journal.pone.0085379
SGUL Authors: He, Taigang
![[img]](https://openaccess.sgul.ac.uk/104829/1.hassmallThumbnailVersion/pone.0085379.pdf) ![](https://openaccess.sgul.ac.uk/104829/1.haspreviewThumbnailVersion/pone.0085379.pdf) Preview |
|
["document_typename_application/pdf; charset=binary" not defined]
Published Version
Download (1MB)
| Preview
|
Abstract
BACKGROUND: Myocardial siderosis is the most common cause of death in patients with beta thalassemia major(TM). This study aimed at investigating the occurrence, prevalence and severity of cardiac iron overload in a young Chinese population with beta TM.
METHODS AND RESULTS: We analyzed T2* cardiac magnetic resonance (CMR), left ventricular ejection fraction (LVEF) and serum ferritin (SF) in 201 beta TM patients. The median age was 9 years old. Patients received an average of 13 units of blood per year. The median SF level was 4536 ng/ml and 165 patients (82.1%) had SF>2500 ng/ml. Myocardial iron overload was detected in 68 patients (33.8%) and severe myocardial iron overload was detected in 26 patients (12.6%). Twenty-two patients ≤10 years old had myocardial iron overload, three of whom were only 6 years old. No myocardial iron overload was detected under the age of 6 years. Median LVEF was 64% (measured by CMR in 175 patients). Five of 6 patients with a LVEF<56% and 8 of 10 patients with cardiac disease had myocardial iron overload.
CONCLUSIONS: The TM patients under follow-up at this regional centre in China patients are younger than other reported cohorts, more poorly-chelated, and have a high burden of iron overload. Myocardial siderosis occurred in patients younger than previously reported, and was strongly associated with impaired LVEF and cardiac disease. For such poorly-chelated TM patients, our data shows that the first assessment of cardiac T2* should be performed as early as 6 years old.
Statistics
Item downloaded times since 05 Mar 2014.
Actions (login required)
![Edit Item](/style/images/action_view.png) |
Edit Item |