Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.

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Shah, T; Engmann, J; Dale, C; Shah, S; White, J; Giambartolomei, C; McLachlan, S; Zabaneh, D; Cavadino, A; Finan, C; et al. Shah, T; Engmann, J; Dale, C; Shah, S; White, J; Giambartolomei, C; McLachlan, S; Zabaneh, D; Cavadino, A; Finan, C; Wong, A; Amuzu, A; Ong, K; Gaunt, T; Holmes, MV; Warren, H; Swerdlow, DI; Davies, TL; Drenos, F; Cooper, J; Sofat, R; Caulfield, M; Ebrahim, S; Lawlor, DA; Talmud, PJ; Humphries, SE; Power, C; Hypponen, E; Richards, M; Hardy, R; Kuh, D; Wareham, N; Langenberg, C; Ben-Shlomo, Y; Day, IN; Whincup, P; Morris, R; Strachan, MW; Price, J; Kumari, M; Kivimaki, M; Plagnol, V; Dudbridge, F; Whittaker, JC; Casas, JP; Hingorani, AD; UCLEB Consortium (2013) Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. PLoS One, 8 (8). e71345 - e71345 (11). ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0071345
SGUL Authors: Whincup, Peter Hynes

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Official URL: https://doi.org/10.1371/journal.pone.0071345

Abstract

Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.

Item Type:

Article

Additional Information:

PMCID: PMC3748096. Copyright: © 2013 Shah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

SGUL Research Institute / Research Centre:

Academic Structure > Population Health Research Institute (INPH)

Journal or Publication Title:

PLoS One

ISSN:

1932-6203

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