Callister, ME; Griffiths, MJ; Nicholson, AG; Leonard, A; Johnson, EM; Polkey, MI; Kerr, JR
(2004)
A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus.
JOURNAL OF CLINICAL PATHOLOGY, 57 (9).
991 - 992 (2).
ISSN 0021-9746
https://doi.org/10.1136/jcp.2003.014449
SGUL Authors: Kerr, Jonathan Richard
Full text not available from this repository.
Abstract
This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granulomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1–D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection.
Item Type: |
Article
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Additional Information: |
PubMed ID: 15333665 |
Keywords: |
Adult, Aspergillosis, Aspergillus fumigatus, Fatal Outcome, Female, Humans, Liver, Lung Diseases, Fungal, Lymph Nodes, Mycological Typing Techniques, Pregnancy, Pregnancy Complications, Infectious, Spleen, Spores, Fungal, Science & Technology, Life Sciences & Biomedicine, Pathology |
Journal or Publication Title: |
JOURNAL OF CLINICAL PATHOLOGY |
ISSN: |
0021-9746 |
Related URLs: |
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Dates: |
Date | Event |
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1 September 2004 | Published |
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Web of Science ID: |
WOS:000223594100019 |
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URI: |
https://openaccess.sgul.ac.uk/id/eprint/102394 |
Publisher's version: |
https://doi.org/10.1136/jcp.2003.014449 |
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