Tradtrantip, L; Zhang, H; Saadoun, S; Phuan, PW; Lam, C; Papadopoulos, MC; Bennett, JL; Verkman, AS
(2012)
Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.
Ann Neurol, 71 (3).
314 - 322.
https://doi.org/10.1002/ana.22657
SGUL Authors: Papadopoulos, Marios Saadoun, Samira
Abstract
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO-immunoglobulin [Ig]G) against astrocyte water channel aquaporin-4 (AQP4) cause complement- and cell-mediated astrocyte damage with consequent neuroinflammation and demyelination. Current NMO therapies, which have limited efficacy, include immunosuppression and plasma exchange. The objective of this study was to develop a potential new NMO therapy based on blocking of pathogenic NMO-IgG binding to its target, AQP4.
| Item Type: | Article | ||||
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| Additional Information: | PMCID: PMC3314396 | ||||
| Keywords: | Animals, Animals, Newborn, Antibodies, Monoclonal, Aquaporin 4, Binding Sites, Antibody, Binding, Competitive, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, Humans, Immunoglobulin G, Mice, Mice, Knockout, Neuromyelitis Optica, Organ Culture Techniques, Protein Binding, Recombinant Proteins | ||||
| SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS) |
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| Journal or Publication Title: | Ann Neurol | ||||
| Dates: |
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| PubMed ID: | 22271321 | ||||
| Web of Science ID: | 22271321 | ||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/101645 | ||||
| Publisher's version: | https://doi.org/10.1002/ana.22657 |
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