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Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

Wilk, JB; Shrine, NR; Loehr, LR; Zhao, JH; Manichaikul, A; Lopez, LM; Smith, AV; Heckbert, SR; Smolonska, J; Tang, W; et al. Wilk, JB; Shrine, NR; Loehr, LR; Zhao, JH; Manichaikul, A; Lopez, LM; Smith, AV; Heckbert, SR; Smolonska, J; Tang, W; Loth, DW; Curjuric, I; Hui, J; Cho, MH; Latourelle, JC; Henry, AP; Aldrich, M; Bakke, P; Beaty, TH; Bentley, AR; Borecki, IB; Brusselle, GG; Burkart, KM; Chen, TH; Couper, D; Crapo, JD; Davies, G; Dupuis, J; Franceschini, N; Gulsvik, A; Hancock, DB; Harris, TB; Hofman, A; Imboden, M; James, AL; Khaw, KT; Lahousse, L; Launer, LJ; Litonjua, A; Liu, Y; Lohman, KK; Lomas, DA; Lumley, T; Marciante, KD; McArdle, WL; Meibohm, B; Morrison, AC; Musk, AW; Myers, RH; North, KE; Postma, DS; Psaty, BM; Rich, SS; Rivadeneira, F; Rochat, T; Rotter, JI; Artigas, MS; Starr, JM; Uitterlinden, AG; Wareham, NJ; Wijmenga, C; Zanen, P; Province, MA; Silverman, EK; Deary, IJ; Palmer, LJ; Cassano, PA; Gudnason, V; Barr, RG; Loos, RJ; Strachan, DP; London, SJ; Boezen, HM; Probst-Hensch, N; Gharib, SA; Hall, IP; O'Connor, GT; Tobin, MD; Stricker, BH (2012) Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med, 186 (7). 622 - 632. https://doi.org/10.1164/rccm.201202-0366OC
SGUL Authors: Strachan, David Peter

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Abstract

Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known.

Item Type: Article
Additional Information: PMCID: PMC3480517
Keywords: Aged, Female, Forced Expiratory Volume, Genome-Wide Association Study, Humans, Male, Middle Aged, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Receptors, Nicotinic, Receptors, Serotonin, 5-HT4, Smoking, Vital Capacity
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Am J Respir Crit Care Med
Dates:
DateEvent
1 October 2012Published
PubMed ID: 22837378
Web of Science ID: 22837378
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URI: https://openaccess.sgul.ac.uk/id/eprint/101620
Publisher's version: https://doi.org/10.1164/rccm.201202-0366OC

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