Burn, J;
Gerdes, AM;
Macrae, F;
Mecklin, JP;
Moeslein, G;
Olschwang, S;
Eccles, D;
Evans, DG;
Maher, ER;
Bertario, L;
et al.
Burn, J; Gerdes, AM; Macrae, F; Mecklin, JP; Moeslein, G; Olschwang, S; Eccles, D; Evans, DG; Maher, ER; Bertario, L; Bisgaard, ML; Dunlop, MG; Ho, JW; Hodgson, SV; Lindblom, A; Lubinski, J; Morrison, PJ; Murday, V; Ramesar, R; Side, L; Scott, RJ; Thomas, HJ; Vasen, HF; Barker, G; Crawford, G; Elliott, F; Movahedi, M; Pylvanainen, K; Wijnen, JT; Fodde, R; Lynch, HT; Mathers, JC; Bishop, DT; CAPP2 Investigators
(2011)
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.
Lancet, 378 (9809).
2081 - 2087.
ISSN 1474-547X
https://doi.org/10.1016/S0140-6736(11)61049-0
SGUL Authors: Hodgson, Shirley Victoria
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Abstract
Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint. The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer; we now report long-term follow-up of participants randomly assigned to aspirin or placebo.
| Item Type: | Article |
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| Additional Information: | PMCID: PMC3243929 |
| Keywords: | Adenoma, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Chemoprevention, Colorectal Neoplasms, Hereditary Nonpolyposis, Dietary Carbohydrates, Double-Blind Method, Heterozygote, Humans, Starch |
| SGUL Research Institute / Research Centre: | Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS) |
| Journal or Publication Title: | Lancet |
| ISSN: | 1474-547X |
| PubMed ID: | 22036019 |
| Web of Science ID: | 22036019 |
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/101069 |
| Publisher's version: | https://doi.org/10.1016/S0140-6736(11)61049-0 |
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