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High tuberculosis incidence among people living with diabetes in Indonesia.

McAllister, SM; Koesoemadinata, RC; Santoso, P; Soetedjo, NNM; Kamil, A; Permana, H; Ruslami, R; Critchley, JA; van Crevel, R; Hill, PC; et al. McAllister, SM; Koesoemadinata, RC; Santoso, P; Soetedjo, NNM; Kamil, A; Permana, H; Ruslami, R; Critchley, JA; van Crevel, R; Hill, PC; Alisjahbana, B (2020) High tuberculosis incidence among people living with diabetes in Indonesia. Trans R Soc Trop Med Hyg, 114 (2). pp. 79-85. ISSN 1878-3503 https://doi.org/10.1093/trstmh/trz100
SGUL Authors: Critchley, Julia

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Abstract

BACKGROUND: Data regarding the incidence of tuberculosis (TB) among people living with diabetes (PLWD) in TB-endemic settings are scarce. We examined TB incidence among PLWD in Indonesia who had previously been screened for latent TB infection (LTBI) and TB disease. METHODS: PLWD (≥18 y of age) in an urban setting were examined a mean 3.4 y after they had been screened for active TB and LTBI. Data on subsequent TB diagnosis were collected by interview and with chest X-ray, sputum smear and Mycobacterium tuberculosis culture. TB incidence rates were stratified for baseline LTBI status, as determined by the QuantiFERON interferon-gamma release assay (IGRA). RESULTS: Of 590 PLWD, 101 had died and 163 could not be contacted or refused. Among the 326 who were re-examined, 6 (1.8%; 95% confidence interval [CI] 0.7 to 4.0) reported being diagnosed already and a further 5 were diagnosed with active TB (1.5%; 95% CI 0.50 to 3.5). The TB incidence rate was 9.85 (95% CI 4.03 to 15.68) per 1000 person-years. TB incidence was higher among PLWD with baseline LTBI (17.13; 95% CI 5.25 to 29.00/1000 person-years) compared with those without LTBI (4.79; 95% CI -0.63 to 10.21), with an incidence rate ratio of 3.57 (95% CI 0.86 to 20.92; p=0.054). CONCLUSIONS: PLWD with LTBI in Indonesia and similar settings are likely to benefit from TB preventive therapy.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Transactions of the Royal Society of Tropical Medicine and Hygiene following peer review. The version of record Susan M McAllister, Raspati C Koesoemadinata, Prayudi Santoso, Nanny N M Soetedjo, Abdul Kamil, Hikmat Permana, Rovina Ruslami, Julia A Critchley, Reinout van Crevel, Philip C Hill, Bachti Alisjahbana, High tuberculosis incidence among people living with diabetes in Indonesia, Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 114, Issue 2, February 2020, Pages 79–85 is available online at: https://doi.org/10.1093/trstmh/trz100
Keywords: diabetes mellitus, incidence, tuberculosis, 0605 Microbiology, 1108 Medical Microbiology, 1117 Public Health And Health Services, Tropical Medicine
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Trans R Soc Trop Med Hyg
ISSN: 1878-3503
Language: eng
Dates:
DateEvent
February 2020Published
11 November 2019Published Online
22 August 2019Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
305279Seventh Framework Programmehttp://dx.doi.org/10.13039/501100004963
PubMed ID: 31711230
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111395
Publisher's version: https://doi.org/10.1093/trstmh/trz100

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