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Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens

Jacquet, A; Robinson, C (2020) Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens. Allergy, 75 (1). pp. 33-53. ISSN 1398-9995 https://doi.org/10.1111/all.13940
SGUL Authors: Robinson, Clive

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Abstract

House dust mites (HDMs) are sources of an extensive repertoire of allergens responsible for a range of allergic conditions. Technological advances have accelerated the identification of these allergens and characterized their putative roles within HDMs. Understanding their functional bioactivities is illuminating how they interact with the immune system to cause disease and how interrelations between them are essential to maximize allergic responses. Two types of allergen bioactivity, namely proteolysis and peptidolipid/lipid binding, elicit IgE and stimulate bystander responses to unrelated allergens. Much of this influence arises from Toll‐like receptor (TLR) 4 or TLR2 signalling and, in the case of protease allergens, the activation of additional pleiotropic effectors with strong disease linkage. Of related interest is the interaction of HDM allergens with common components of the house dust matrix, through either their binding to allergens or their autonomous modulation of immune receptors. Herein, we provide a contemporary view of how proteolysis, lipid‐binding activity and interactions with polysaccharides and polysaccharide molecular recognition systems coordinate the principal responses which underlie allergy. The power of the catalytically competent group 1 HDM protease allergen component is demonstrated by a review of disclosures surrounding the efficacy of novel inhibitors produced by structure‐based design.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Jacquet, A, Robinson, C. Proteolytic, lipidergic and polysaccharide molecular recognition shape innate responses to house dust mite allergens. Allergy. 2020; 75: 33– 53, which has been published in final form at https://doi.org/10.1111/all.13940. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: House dust mite, Toll-like receptors, lipid-binding protein, polysaccharide, protease allergen, 1107 Immunology, Allergy
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Allergy
ISSN: 1398-9995
Language: eng
Dates:
DateEvent
8 January 2020Published
11 July 2019Published Online
23 May 2019Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
TRG5680005Thailand Research Fundhttp://dx.doi.org/10.13039/501100004396
NRU59-003-HROffice of Higher Education CommissionUNSPECIFIED
083625Wellcome Trusthttp://dx.doi.org/10.13039/100004440
SB-60-003-03Center of Excellence on Medical BiotechnologyUNSPECIFIED
GRB-BSS_83_59_30_24Chulalongkorn Universityhttp://dx.doi.org/10.13039/501100002873
PubMed ID: 31166610
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/110916
Publisher's version: https://doi.org/10.1111/all.13940

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