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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects

Middeldorp, CM; Felix, JF; Mahajan, A; Horikoshi, M; Robertson, NR; Beaumont, RN; Bradfield, JP; Bustamante, M; Cousminer, DL; Day, FR; et al. Middeldorp, CM; Felix, JF; Mahajan, A; Horikoshi, M; Robertson, NR; Beaumont, RN; Bradfield, JP; Bustamante, M; Cousminer, DL; Day, FR; De Silva, NM; Guxens, M; Mook-Kanamori, DO; St Pourcain, B; Warrington, NM; Adair, LS; Ahlqvist, E; Ahluwali, TS; Almgren, P; Ang, W; Atalay, M; Auvinen, J; Bartels, M; Beckmann, JS; Bilbao, JR; Bond, T; Borja, JB; Cavadino, A; Charoen, P; Chen, Z; Coin, L; Cooper, C; Curtin, JA; Custovic, A; Das, S; Davies, GE; Dedoussis, GV; Duijts, L; Eastwood, PR; Eliasen, AU; Elliott, P; Eriksson, JG; Estivill, X; Fadista, J; Fedko, IO; Frayling, TM; Gaillard, R; Gauderman, WJ; Geller, F; Gilliland, F; Gilsanz, V; Granell, R; Grarup, N; Groop, L; Hadley, D; Hakonarson, H; Hansen, T; Hartman, CA; Hattersley, AT; Hayes, MG; Hebebrand, J; Heinrich, J; Helgeland, Ø; Henders, AK; Henderson, J; Henrikson, TB; Hirschhorn, JN; Hivert, M-F; Hocher, B; Holloway, JW; Holt, P; Hottenga, J-J; Hyppönen, E; Iñíguez, C; Johansson, S; Jugessur, A; Kähönen, M; Kalkwarf, HJ; Kaprio, J; Karhunen, V; Kemp, JP; Kerkhof, M; Koppelman, GH; Körner, A; Kotecha, S; Kreiner-Møller, E; Kulohoma, B; Kumar, A; Kutalik, Z; Lahti, J; Lappe, JM; Larsson, H; Lehtimäki, T; Lewin, AM; Li, J; Lichtenstein, P; Lindgren, CM; Lindi, V; Linneberg, A; Liu, X; Liu, J; Lowe Jr, WL; Lundström, S; Lyytikäinen, L-P; Ma, RCW; Macé, A; Mägi, R; Magnus, P; Mamun, AA; Mannikko, M; Martin, NG; Mbarek, H; McCarthy, NS; Medland, SE; Melbye, M; Melén, E; Mohlke, KL; Monnereau, C; Morgen, CS; Morris, AP; Murray, JC; Myhre, R; Najman, JM; Nivard, MG; Nohr, EA; Nolte, IM; Ntalla, I; O'Reilly, P; Oberfield, SE; Oken, E; Oldehinkel, AJ; Pahkala, K; Palviainen, T; Panoutsopoulou, K; Pedersen, O; Pennell, CE; Pershagen, G; Pitkänen, N; Plomin, R; Power, C; Prasad, RB; Prokopenko, I; Pulkkinen, L; Räikkönen, K; Raitakari, OT; Reynolds, RM; Richmond, RC; Rivadeneira, F; Rodriguez, A; Rose, RJ; Salem, R; Santa-Marina, L; Saw, S-M; Schnurr, TM; Scott, JG; Selzam, S; Shepherd, JA; Simpson, A; Skotte, L; Sleiman, PMA; Snieder, H; Sørensen, TIA; Standl, M; Steegers, EAP; Strachan, DP; Straker, L; Strandberg, T; Taylor, M; Teo, Y-Y; Thiering, E; Torrent, M; Tyrrell, J; Uitterlinden, AG; van Beijsterveldt, T; van der Most, PJ; van Duijn, CM; Viikari, J; Vilor-Tejedor, N; Vogelezang, S; Vonk, JM; Vrijkotte, TGM; Vuoksimaa, E; Wang, CA; Watkins, WJ; Wichmann, H-E; Willemsen, G; Williams, GM; Wilson, JFW; Wray, NR; Xu, S; Xu, C-J; Yaghootkar, H; Yi, L; Zafarmand, MH; Zeggini, E; Zemel, BS; Hinney, A; Lakka, TA; Whitehouse, AJO; Sunyer, J; Widén, EE; Feenstra, B; Sebert, S; Jacobsson, B; Njølstad, PR; Stoltenberg, C; Davey Smith, G; Lawlor, DA; Paternoster, L; Timpson, NJ; Ong, KK; Bisgaard, H; Bønnelykke, K; Jaddoe, VWV; Tiemeier, H; Järvelin, M-R; Evans, DM; Perry, JRB; Grant, SFA; Boomsma, DI; Freathy, RM; McCarthy, MI (2019) The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 34 (3). pp. 279-300. ISSN 0393-2990 https://doi.org/10.1007/s10654-019-00502-9
SGUL Authors: Strachan, David Peter

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Abstract

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.

Item Type: Article
Additional Information: © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: 1117 Public Health And Health Services, Epidemiology
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: EUROPEAN JOURNAL OF EPIDEMIOLOGY
ISSN: 0393-2990
Dates:
DateEvent
March 2019Published
18 March 2019Published Online
25 January 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
102215/2/13/2Wellcome Trusthttp://dx.doi.org/10.13039/100004440
G0000934Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
068545/Z/02Wellcome Trusthttp://dx.doi.org/10.13039/100004440
076113/B/04/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
WT 084762Wellcome Trusthttp://dx.doi.org/10.13039/100004440
G0601361Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/K002449/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/L012693/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/M021475/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
G0901245Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
WT104150Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT098395Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT098051Wellcome Trusthttp://dx.doi.org/10.13039/100004440
WT205915Wellcome Trusthttp://dx.doi.org/10.13039/100004440
C18281/A19169Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
098051Wellcome Trusthttp://dx.doi.org/10.13039/100004440
MC_UU_12013/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_00011/6Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
WT088806Wellcome Trusthttp://dx.doi.org/10.13039/100004440
202802/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
C18281/A19169Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
MC_UU_12013_4Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
090532Wellcome Trusthttp://dx.doi.org/10.13039/100004440
098381Wellcome Trusthttp://dx.doi.org/10.13039/100004440
203141Wellcome Trusthttp://dx.doi.org/10.13039/100004440
URI: http://openaccess.sgul.ac.uk/id/eprint/110590
Publisher's version: https://doi.org/10.1007/s10654-019-00502-9

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