SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Heterocellular induction of interferon by negative-sense RNA viruses

Chen, S; Short, JA; Young, DF; Killip, MJ; Schneider, M; Goodbourn, S; Randall, RE (2010) Heterocellular induction of interferon by negative-sense RNA viruses. VIROLOGY, 407 (2). 247 - 255. ISSN 0042-6822 https://doi.org/10.1016/j.virol.2010.08.008
SGUL Authors: Goodbourn, Stephen Edward

[img]
Preview
["document_typename_application/pdf; charset=binary" not defined] Published Version
Available under License St George's repository terms & conditions.

Download (2MB) | Preview

Abstract

The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells.

Item Type: Article
Additional Information: Copyright © 2010 Elsevier Inc. Under a Creative Commons license CC BY 3.0
Keywords: Animals, Bunyamwera virus, Cell Line, Tumor, Cercopithecus aethiops, Host-Pathogen Interactions, Humans, Influenza A virus, Interferon Type I, Interferon-alpha, Interferon-beta, Kidney, Lung, Paramyxoviridae, Species Specificity, Vero Cells, Virus Replication, Science & Technology, Life Sciences & Biomedicine, Virology, Paramyxovirus, Influenza bunyamwera, Interferon, PARAMYXOVIRUS V-PROTEINS, INDUCED ANTIVIRAL STATE, RIG-I, MONOCLONAL-ANTIBODIES, ANTIGENIC DIFFERENCES, GENE-EXPRESSION, SIMIAN VIRUS-5, CELLS, BETA, ACTIVATION
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: VIROLOGY
ISSN: 0042-6822
Related URLs:
Dates:
DateEvent
25 November 2010Published
Web of Science ID: WOS:000283480100009
Download EPMC Full text (HTML)
URI: https://openaccess.sgul.ac.uk/id/eprint/565
Publisher's version: https://doi.org/10.1016/j.virol.2010.08.008

Actions (login required)

Edit Item Edit Item