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Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study.

Rijken, MJ; Moroski, WE; Kiricharoen, S; Karunkonkowit, N; Stevenson, G; Ohuma, EO; Noble, JA; Kennedy, SH; McGready, R; Papageorghiou, AT; et al. Rijken, MJ; Moroski, WE; Kiricharoen, S; Karunkonkowit, N; Stevenson, G; Ohuma, EO; Noble, JA; Kennedy, SH; McGready, R; Papageorghiou, AT; Nosten, FH (2012) Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study. MALARIA JOURNAL, 11 (5). ISSN 1475-2875 https://doi.org/10.1186/1475-2875-11-5
SGUL Authors: Papageorghiou, Aris

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Abstract

Background: The presence of malaria parasites and histopathological changes in the placenta are associated with a reduction in birth weight, principally due to intrauterine growth restriction. The aim of this study was to examine the feasibility of studying early pregnancy placental volumes using three-dimensional (3D) ultrasound in a malaria endemic area, as a small volume in the second trimester may be an indicator of intra-uterine growth restriction and placental insufficiency. Methods: Placenta volumes were acquired using a portable ultrasound machine and a 3D ultrasound transducer and estimated using the Virtual Organ Computer-aided AnaLysis (VOCAL) image analysis software package. Intraobserver reliability and limits of agreement of the placenta volume measurements were calculated. Polynomial regression models for the mean and standard deviation as a function of gestational age for the placental volumes of uninfected women were created and tested. Based on these equations each measurement was converted into a z -score. The z-scores of the placental volumes of malaria infected and uninfected women were then compared. Results: Eighty-four women (uninfected = 65; infected = 19) with a posterior placenta delivered congenitally normal, live born, single babies. The mean placental volumes in the uninfected women were modeled to fit 5th, 10th, 50th, 90th and 95th centiles for 14-24 weeks’ gestation. Most placenta volumes in the infected women were below the 50th centile for gestational age; most of those with Plasmodium falciparum were below the 10th centile. The 95% intra-observer limits of agreement for first and second measurements were ± 37.0 mL and ± 25.4 mL at 30 degrees and 15 degrees rotation respectively. Conclusion: The new technique of 3D ultrasound volumetry of the placenta may be useful to improve our understanding of the pathophysiological constraints on foetal growth caused by malaria infection in early pregnancy.

Item Type: Article
Additional Information: © 2011 Rijken et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Birth Weight, Female, Fetal Growth Retardation, Gestational Age, Humans, Imaging, Three-Dimensional, Infant, Malaria, Falciparum, Observer Variation, Pilot Projects, Placenta, Placental Insufficiency, Plasmodium falciparum, Pregnancy, Pregnancy Trimester, Second, Reproducibility of Results, Ultrasonography, Prenatal
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: MALARIA JOURNAL
ISSN: 1475-2875
Dates:
DateEvent
5 January 2012Published
PubMed ID: 22222152
Web of Science ID: 22222152
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URI: https://openaccess.sgul.ac.uk/id/eprint/2010
Publisher's version: https://doi.org/10.1186/1475-2875-11-5

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