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Lung Function and Risk of Type 2 Diabetes and Fatal and Nonfatal Major Coronary Heart Disease Events: Possible Associations With Inflammation

Wannamethee, SG; Shaper, AG; Rumley, A; Sattar, N; Whincup, PH; Thomas, MC; Lowe, GD (2010) Lung Function and Risk of Type 2 Diabetes and Fatal and Nonfatal Major Coronary Heart Disease Events: Possible Associations With Inflammation. DIABETES CARE, 33 (9). 1990 - 1996. ISSN 0149-5992 https://doi.org/10.2337/dc10-0324
SGUL Authors: Whincup, Peter Hynes

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Abstract

OBJECTIVE — We prospectively examined the relationship between lung function and risk of type-2 diabetes and fatal and nonfatal coronary heart disease (CHD) events and investigated the hypothesis that inflammation may underlie these associations. RESEARCH DESIGN AND METHODS— A prospective study of 4,434 men aged 40–59 years with no history of cardiovascular disease (CHD or stroke) or diabetes drawn from general practices in 24 British towns and followed up for 20 years. RESULTS— There were 680 major CHD events (276 fatal, 404 nonfatal) and 256 incident type 2 diabetes during the 20 years follow-up. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) but not FEV1-to-FVC ratio were significantly and inversely associated with incident type 2 diabetes and fatal CHD events (not nonfatal events) after adjustment for age, potential confounders, and metabolic risk factors. The adjusted relative risk (RR) for type 2 diabetes (Quartile 1 vs. Quartile 4) were 1.59 (1.07–2.56) and 1.74 (1.16 –2.61) for FVC and FEV1, respectively (P�0.03 and P�0.04 for trend). The corresponding RR for fatal CHD were 1.48 (1.00 –2.21) and 1.81 (1.19 –2.76) (P � 0.002 and P � 0.0003 for trend). Lung function was significantly and inversely associated with C-reactive protein and interleukin-6; the inverse associations with type 2 diabetes for FVC and FEV1 were attenuated after further adjustment for these factors (P�0.14 and P�0.11 for trend) but remained significant for fatal CHD (P�0.03 and P � 0.01, respectively). CONCLUSIONS — Restrictive rather than obstructive impairment of lung function is associated with incident type 2 diabetes (and fatal CHD) with both associations partially explained by traditional and metabolic risk factors and inflammation.

Item Type: Article
Additional Information: Copyright © 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
Keywords: Adult, Coronary Disease, Diabetes Mellitus, Type 2, Humans, Inflammation, Lung, Lung Diseases, Obstructive, Male, Middle Aged, Prospective Studies, Risk Factors, Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, ENDOCRINOLOGY & METABOLISM, SENSITIVE PLASMA-PROTEINS, ATHEROSCLEROSIS RISK, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, METABOLIC SYNDROME, COMMUNITIES, HEALTH, COHORT, PREDICTOR, ADULTS, Endocrinology & Metabolism, 11 Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: DIABETES CARE
ISSN: 0149-5992
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Dates:
DateEvent
1 September 2010Published
Web of Science ID: WOS:000282560300017
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URI: https://openaccess.sgul.ac.uk/id/eprint/1487
Publisher's version: https://doi.org/10.2337/dc10-0324

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