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New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs.

Ráduly, Z; Szabó, A; Mézes, M; Balatoni, I; Price, RG; Dockrell, ME; Pócsi, I; Csernoch, L (2023) New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs. Front Microbiol, 14. p. 1085818. ISSN 1664-302X https://doi.org/10.3389/fmicb.2023.1085818
SGUL Authors: Dockrell, Mark Edward Carl

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Abstract

The gradual spread of Aspergilli worldwide is adding to the global shortage of food and is affecting its safe consumption. Aspergillus-derived mycotoxins, including aflatoxins and ochratoxin A, and fumonisins (members of the fusariotoxin group) can cause pathological damage to vital organs, including the kidney or liver. Although the kidney functions as the major excretory system in mammals, monitoring and screening for mycotoxin induced nephrotoxicity is only now a developmental area in the field of livestock feed toxicology. Currently the assessment of individual exposure to mycotoxins in man and animals is usually based on the analysis of toxin and/or metabolite contamination in the blood or urine. However, this requires selective and sensitive analytical methods (e.g., HPLC-MS/MS), which are time consuming and expensive. The toxicokinetic of mycotoxin metabolites is becoming better understood. Several kidney biomarkers are used successfully in drug development, however cost-efficient, and reliable kidney biomarkers are urgently needed for monitoring farm animals for early signs of kidney disease. β2-microglobulin (β2-MG) and N-acetyl-β-D-glucosaminidase (NAG) are the dominant biomarkers employed routinely in environmental toxicology research, while kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are also emerging as effective markers to identify mycotoxin induced nephropathy. Pigs are exposed to mycotoxins due to their cereal-based diet and are particularly susceptible to Aspergillus mycotoxins. In addition to commonly used diagnostic markers for nephrotoxicity including plasma creatinine, NAG, KIM-1 and NGAL can be used in pigs. In this review, the currently available techniques are summarized, which are used for screening mycotoxin induced nephrotoxicity in farm animals. Possible approaches are considered, which could be used to detect mycotoxin induced nephropathy.

Item Type: Article
Additional Information: Copyright © 2023 Ráduly, Szabó, Mézes, Balatoni, Price, Dockrell, Pócsi and Csernoch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: KIM-1, NAG, NGAL biomarkers, mycotoxin induced nephrotoxicity, animal toxicity, kidney biomarkers, mycotoxins, nephrotoxicity, nephrotoxicity, KIM-1, kidney biomarkers, mycotoxins, animal toxicity, NAG, NGAL biomarkers, mycotoxin induced nephrotoxicity, 0502 Environmental Science and Management, 0503 Soil Sciences, 0605 Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Front Microbiol
ISSN: 1664-302X
Language: eng
Dates:
DateEvent
14 April 2023Published
24 March 2023Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
GINOP-2.3.2-15-2016-00062European UnionUNSPECIFIED
2018-1.2.1-NKP-2018-00002National Research, Development and Innovation Fund of HungaryUNSPECIFIED
ELKH-MATE 13003Hungarian Academy of SciencesUNSPECIFIED
RRF-2.3.1-21-2022-00007Hungarian National LaboratoryUNSPECIFIED
TKP2021-EGA-18National Research, Development and Innovation Fund of HungaryUNSPECIFIED
core17-2022/23Kidney Fundhttp://dx.doi.org/10.13039/100015760
UNSPECIFIEDEuropean STEP research ProgrammeUNSPECIFIED
PubMed ID: 37125184
Web of Science ID: WOS:000977904100001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/115523
Publisher's version: https://doi.org/10.3389/fmicb.2023.1085818

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