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Obliterated cavum septi pellucidi: Clinical significance and role of fetal magnetic resonance.

Fantasia, I; Ciardo, C; Bracalente, G; Filippi, E; Murru, FM; Spezzacatene, A; Bin, M; Mendez Quintero, O; Montaguti, E; Lees, C; et al. Fantasia, I; Ciardo, C; Bracalente, G; Filippi, E; Murru, FM; Spezzacatene, A; Bin, M; Mendez Quintero, O; Montaguti, E; Lees, C; Papanikolaou, K; Pilu, G; Prefumo, F; Thilaganathan, B; Stampalija, T (2023) Obliterated cavum septi pellucidi: Clinical significance and role of fetal magnetic resonance. Acta Obstet Gynecol Scand, 102 (6). pp. 744-750. ISSN 1600-0412 https://doi.org/10.1111/aogs.14575
SGUL Authors: Thilaganathan, Baskaran

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Abstract

INTRODUCTION: The objective of this study was to describe a cohort of fetuses with an ultrasound prenatal diagnosis of obliterated cavum septi pellucidi (oCSP) with the aim to explore the rate of associated malformations, the progression during pregnancy and the role of fetal magnetic resonance imaging (MRI). MATERIAL AND METHODS: This was a retrospective multicenter international study of fetuses diagnosed with oCSP in the second trimester with available fetal MRI and subsequent ultrasound and/or fetal MRI follow-up in the third trimester. Where available, postnatal data were collected to obtain information on neurodevelopment. RESULTS: We identified 45 fetuses with oCSP at 20.5 weeks (interquartile range 20.1-21.1). oCSP was apparently isolated at ultrasound in 89% (40/45) and fetal MRI found additional findings in 5% (2/40) of cases, including polymicrogyria and microencephaly. In the remaining 38 fetuses, fetal MRI found a variable amount of fluid in CSP in 74% (28/38) and no fluid in 26% (10/38). Ultrasound follow-up at or after 30 weeks confirmed the diagnosis of oCSP in 32% (12/38) while fluid was visible in 68% (26/38). At follow-up MRI, performed in eight pregnancies, there were periventricular cysts and delayed sulcation with persistent oCSP in one case. Among the remaining cases with normal follow-up ultrasound and fetal MRI findings, the postnatal outcome was normal in 89% of cases (33/37) and abnormal in 11% (4/37): two with isolated speech delay, and two with neurodevelopmental delay secondary to postnatal diagnosis of Noonan syndrome at 5 years in one case and microcephaly with delayed cortical maturation at 5 months in the other. CONCLUSIONS: Apparently isolated oCSP at mid-pregnancy is a transient finding with the visualization of the fluid later in pregnancy in up to 70% of cases. At referral, associated defects can be found in around 11% of cases at ultrasound and 8% at fetal MRI indicating the need for a detailed evaluation by expert physicians when oCSP is suspected.

Item Type: Article
Additional Information: © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: cavum septi pellucidi, fetal brain, fetal magnetic resonance, neurosonography, postnatal neurodevelopmental outcome, cavum septi pellucidi, fetal brain, fetal magnetic resonance, neurosonography, postnatal neurodevelopmental outcome, 1114 Paediatrics and Reproductive Medicine, 1117 Public Health and Health Services, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Acta Obstet Gynecol Scand
ISSN: 1600-0412
Language: eng
Dates:
DateEvent
22 May 2023Published
14 April 2023Published Online
28 March 2023Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
RC 12/21Italian Ministry of HealthUNSPECIFIED
PubMed ID: 37059118
Web of Science ID: WOS:000972144200001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/115409
Publisher's version: https://doi.org/10.1111/aogs.14575

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