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Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.

Cooper, PJ; Figueiredo, CA; Rodriguez, A; Dos Santos, LM; Ribeiro-Silva, RC; Carneiro, VL; Costa, G; Magalhães, T; Dos Santos de Jesus, T; Rios, R; et al. Cooper, PJ; Figueiredo, CA; Rodriguez, A; Dos Santos, LM; Ribeiro-Silva, RC; Carneiro, VL; Costa, G; Magalhães, T; Dos Santos de Jesus, T; Rios, R; da Silva, HBF; Costa, R; Chico, ME; Vaca, M; Alcantara-Neves, N; Rodrigues, LC; Cruz, AA; Barreto, ML (2023) Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme. Clin Transl Allergy, 13 (3). e12232. ISSN 2045-7022 https://doi.org/10.1002/clt2.12232
SGUL Authors: Cooper, Philip John

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Abstract

Asthma is an important health concern in Latin America (LA) where it is associated with variable prevalence and disease burden between countries. High prevalence and morbidity have been observed in some regions, particularly marginalized urban populations. Research over the past 10 years from LA has shown that childhood disease is primarily non-atopic. The attenuation of atopy may be explained by enhanced immune regulation induced by intense exposures to environmental factors such as childhood infections and poor environmental conditions of the urban poor. Non-atopic symptoms are associated with environmental and lifestyle factors including poor living conditions, respiratory infections, psychosocial stress, obesity, and a diet of highly processed foods. Ancestry (particularly African) and genetic factors increase asthma risk, and some of these factors may be specific to LA settings. Asthma in LA tends to be poorly controlled and depends on access to health care and medications. There is a need to improve management and access to medication through primary health care. Future research should consider the heterogeneity of asthma to identify relevant endotypes and underlying causes. The outcome of such research will need to focus on implementable strategies relevant to populations living in resource-poor settings where the disease burden is greatest.

Item Type: Article
Additional Information: © 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Latin America, allergy, asthma, determinants, allergy, asthma, determinants, Latin America
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Clin Transl Allergy
ISSN: 2045-7022
Language: eng
Dates:
DateEvent
26 March 2023Published
15 February 2023Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
072405/Z/03/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
074679/Z/04/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
088862/Z/09/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 36973960
Web of Science ID: WOS:000952128200001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/115336
Publisher's version: https://doi.org/10.1002/clt2.12232

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