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A web-based life-style, exercise and activity intervention for people with progressive multiple sclerosis: Results of a single-arm feasibility study.

Busse, M; Playle, R; Latchem-Hastings, J; Button, K; Lowe, R; Barlow, C; Lloyd, B; Dean-Young, A; Poile, V; Dawes, H; et al. Busse, M; Playle, R; Latchem-Hastings, J; Button, K; Lowe, R; Barlow, C; Lloyd, B; Dean-Young, A; Poile, V; Dawes, H; Davies, F; O'Halloran, R; Tallantyre, E; Edwards, A; Wood, F; Jones, F (2022) A web-based life-style, exercise and activity intervention for people with progressive multiple sclerosis: Results of a single-arm feasibility study. Mult Scler Relat Disord, 57. p. 103388. ISSN 2211-0356 https://doi.org/10.1016/j.msard.2021.103388
SGUL Authors: Jones, Fiona

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Abstract

BACKGROUND: People with progressive Multiple Sclerosis often struggle to access appropriate and inclusive support for regular physical activity. The Lifestyle, Exercise and Activity Package (LEAP-MS) intervention, is a co-designed web-based physical activity intervention for people with progressive Multiple Sclerosis (MS). It consists of two key components; (1) web-based physical activity coaching with physiotherapists using self-management support strategies and 2) an interactive web-based platform including a physical activity information suite, an activity selection and planning tool and a participant-physiotherapist messaging system. We aimed to evaluate recruitment, retention and uptake, in a single arm feasibility study. METHODS: Participants with primary or secondary progressive MS with an Expanded Disability Status Scale score of 6 to 8 were recruited. Assessments included the MS Impact Scale (MSIS-29) and measures of participation at baseline, three and six months. All participants received the intervention which consisted of up to six web-based physiotherapy- led physical activity coaching sessions alongside access to web-based education and activity suites. Recruitment, retention and uptake data were summarised. Pre-defined progression criteria were used to guide feasibility assessment. Clinical outcome data were analysed descriptively. RESULTS: Fifty-eight percent (21/36) of those submitting expressions of interest were recruited; 76% completed follow-up. Pre-specified progression criteria for retention were met but recruitment did not meet progression criteria. The intervention achieved set fidelity criteria. At three months, 12 participants (75%) reported improvements in routine activities after the intervention. MSIS-29 physical scores improved by an average of eight points (95% CI -12.6 to -3.3). Improvements were also seen in MSIS-29 psychological scores and fatigue. Some improvements were maintained at six months. CONCLUSIONS: The LEAP-MS intervention is feasible and associated with improvements in MSIS-29 scores. The intervention facilitated partnership working between physiotherapists and people with progressive MS. Users developed valuable skills in supported self-management by focussing on enhancing physical activity to support overall wellbeing. This work has laid the foundations for a large-scale evaluation of a co-designed intervention with potential for far reaching impact on the lives of people with progressive MS.

Item Type: Article
Additional Information: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Feasibility study, Intervention, Multiple sclerosis, Physical activity, Physiotherapy, Self-management, Exercise, Feasibility Studies, Humans, Internet, Life Style, Multiple Sclerosis, Humans, Multiple Sclerosis, Exercise, Feasibility Studies, Life Style, Internet, 1109 Neurosciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Mult Scler Relat Disord
ISSN: 2211-0356
Language: eng
Dates:
DateEvent
9 February 2022Published
8 November 2021Published Online
5 November 2021Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
81Multiple Sclerosis Societyhttp://dx.doi.org/10.13039/501100000381
PubMed ID: 35158478
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/115245
Publisher's version: https://doi.org/10.1016/j.msard.2021.103388

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