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Sudden cardiac death in the young: A consensus statement on recommended practices for cardiac examination by pathologists from the Society for Cardiovascular Pathology.

Kelly, KL; Lin, PT; Basso, C; Bois, M; Buja, LM; Cohle, SD; d'Amati, G; Duncanson, E; Fallon, JT; Firchau, D; et al. Kelly, KL; Lin, PT; Basso, C; Bois, M; Buja, LM; Cohle, SD; d'Amati, G; Duncanson, E; Fallon, JT; Firchau, D; Fishbein, G; Giordano, C; Leduc, C; Litovsky, SH; Mackey-Bojack, S; Maleszewski, JJ; Michaud, K; Padera, RF; Papadodima, SA; Parsons, S; Radio, SJ; Rizzo, S; Roe, SJ; Romero, M; Sheppard, MN; Stone, JR; Tan, CD; Thiene, G; van der Wal, AC; Veinot, JP (2023) Sudden cardiac death in the young: A consensus statement on recommended practices for cardiac examination by pathologists from the Society for Cardiovascular Pathology. Cardiovasc Pathol, 63. p. 107497. ISSN 1879-1336 https://doi.org/10.1016/j.carpath.2022.107497
SGUL Authors: Sheppard, Mary Noelle

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Abstract

Sudden cardiac death is, by definition, an unexpected, untimely death caused by a cardiac condition in a person with known or unknown heart disease. This major international public health problem accounts for approximately 15-20% of all deaths. Typically more common in older adults with acquired heart disease, SCD also can occur in the young where the cause is more likely to be a genetically transmitted process. As these inherited disease processes can affect multiple family members, it is critical that these deaths are appropriately and thoroughly investigated. Across the United States, SCD cases in those less than 40 years of age will often fall under medical examiner/coroner jurisdiction resulting in scene investigation, review of available medical records and a complete autopsy including toxicological and histological studies. To date, there have not been consistent or uniform guidelines for cardiac examination in these cases. In addition, many medical examiner/coroner offices are understaffed and/or underfunded, both of which may hamper specialized examinations or studies (e.g., molecular testing). Use of such guidelines by pathologists in cases of SCD in decedents aged 1-39 years of age could result in life-saving medical intervention for other family members. These recommendations also may provide support for underfunded offices to argue for the significance of this specialized testing. As cardiac examinations in the setting of SCD in the young fall under ME/C jurisdiction, this consensus paper has been developed with members of the Society of Cardiovascular Pathology working with cardiovascular pathology-trained, practicing forensic pathologists.

Item Type: Article
Additional Information: © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords: Cardiomyopathy, Death in the young, Forensic pathology heart examination, Genomics of sudden death, Hypertrophic cardiomyopathy, Sudden cardiac death, Sudden death, Sudden unexpected death in epilepsy, Humans, Aged, Adult, Infant, Child, Preschool, Child, Adolescent, Young Adult, Pathologists, Death, Sudden, Cardiac, Heart Diseases, Autopsy, Heart, Heart, Humans, Heart Diseases, Death, Sudden, Cardiac, Autopsy, Adolescent, Adult, Aged, Child, Child, Preschool, Infant, Young Adult, Pathologists, Sudden cardiac death, Sudden death, Death in the young, Forensic pathology heart examination, Hypertrophic cardiomyopathy, Genomics of sudden death, Cardiomyopathy, Sudden unexpected death in epilepsy, 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Cardiovasc Pathol
ISSN: 1879-1336
Language: eng
Dates:
DateEvent
22 December 2023Published
12 November 2022Published Online
4 November 2022Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 36375720
Web of Science ID: WOS:000926505600001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/115235
Publisher's version: https://doi.org/10.1016/j.carpath.2022.107497

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