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(2022)
Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality.
J Stroke, 24 (2).
pp. 256-265.
ISSN 2287-6391
https://doi.org/10.5853/jos.2022.00752
SGUL Authors: Zhang, Liqun
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Abstract
BACKGROUND AND PURPOSE: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. METHODS: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). RESULTS: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. CONCLUSIONS: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT.
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| Additional Information: | Copyright © 2022 Korean Stroke Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Keywords: | COVID-19, Cerebral venous thrombosis, Mortality, SARS-CoV-2, Stroke, Vaccine-induced immune thrombotic thrombocytopenia, SVIN COVID-19 Global COVID Stroke Registry, COVID-19, Cerebral venous thrombosis, Vaccine-induced immune thrombotic thrombocytopenia, Mortality, SARS-CoV-2, Stroke, 1103 Clinical Sciences, 1109 Neurosciences | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Institute of Medical & Biomedical Education (IMBE) Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE ) |
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| Journal or Publication Title: | J Stroke | |||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 2287-6391 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | eng | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Dates: |
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| Publisher License: | Creative Commons: Attribution-Noncommercial 4.0 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| PubMed ID: | 35677980 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Web of Science ID: | WOS:000812327500008 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/114920 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher's version: | https://doi.org/10.5853/jos.2022.00752 |
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