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Gestational age at birth and outcome in monochorionic twins with different types of selective fetal growth restriction: A systematic literature review.

El Emrani, S; Groene, SG; Verweij, EJ; Slaghekke, F; Khalil, A; van Klink, JMM; Tiblad, E; Lewi, L; Lopriore, E (2022) Gestational age at birth and outcome in monochorionic twins with different types of selective fetal growth restriction: A systematic literature review. Prenat Diagn, 42 (9). pp. 1094-1110. ISSN 1097-0223 https://doi.org/10.1002/pd.6206
SGUL Authors: Khalil, Asma

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Abstract

This systematic review aims to assess the gestational age at birth and perinatal outcome [intrauterine demise (IUD), neonatal mortality and severe cerebral injury] in monochorionic twins with selective fetal growth restriction (sFGR), according to Gratacós classification based on umbilical artery Doppler flow patterns in the smaller twin. Seventeen articles were included. Gestational age at birth varied from 33.0 to 36.0 weeks in type I, 27.6-32.4 weeks in type II, and 28.3-33.8 weeks in type III. IUD rate differed from 0%-4% in type I to 0%-40% in type II and 0%-23% in type III. Neonatal mortality rate was between 0%-10% in type I, 0%-38% in type II, and 0%-17% in type III. Cerebral injury was present in 0%-2% of type I, 2%-30% of type II and 0%-33% of type III cases. The timing of delivery in sFGR varied substantially among studies, particularly in type II and III. The quality of evidence was moderate due to heterogenous study populations with varying definitions of sFGR and perinatal outcome parameters, as well as a lack of consensus on the use of the Gratacós classification, leading to substantial incomparability. Our review identifies the urgent need for uniform antenatal diagnostic criteria and definitions of outcome parameters.

Item Type: Article
Additional Information: © 2022 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Keywords: 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Prenat Diagn
ISSN: 1097-0223
Language: eng
Dates:
DateEvent
19 August 2022Published
17 July 2022Published Online
3 July 2022Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
2017T075Hartstichtinghttp://dx.doi.org/10.13039/501100002996
PubMed ID: 35808908
Web of Science ID: WOS:000826250600001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/114666
Publisher's version: https://doi.org/10.1002/pd.6206

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