Prior Pulmonary Tuberculosis Is a Risk Factor for Asymptomatic Cryptococcal Antigenemia in a Cohort of Adults With Advanced Human Immunodeficiency Virus Disease.

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Wake, RM; Ismail, NA; Omar, SV; Ismail, F; Tiemessen, CT; Harrison, TS; Jarvis, JN; Govender, NP (2022) Prior Pulmonary Tuberculosis Is a Risk Factor for Asymptomatic Cryptococcal Antigenemia in a Cohort of Adults With Advanced Human Immunodeficiency Virus Disease. Open Forum Infect Dis, 9 (7). ofac202. ISSN 2328-8957 https://doi.org/10.1093/ofid/ofac202
SGUL Authors: Harrison, Thomas Stephen

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Official URL: https://doi.org/10.1093/ofid/ofac202

Abstract

The greater mortality risk among people with advanced human immunodeficiency virus disease and cryptococcal antigenemia, despite treatment, indicates an increased susceptibility to other infections. We found that prior tuberculosis was an independent risk factor for cryptococcal antigenemia (adjusted odds ratio, 2.72; 95% confidence interval, 1.13-6.52; P = .03) among patients with CD4 counts <100 cells/µL.

Item Type:

Article

Additional Information:

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

Keywords:

advanced HIV disease, cryptococcosis, tuberculosis

SGUL Research Institute / Research Centre:

Academic Structure > Infection and Immunity Research Institute (INII)

Journal or Publication Title:

Open Forum Infect Dis

ISSN:

2328-8957

Language:

eng

Dates:

Date	Event
July 2022	Published
17 April 2022	Published Online
12 April 2022	Accepted

Publisher License:

Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0

Projects:

Project ID	Funder	Funder ID
1604.0	Meningitis Research Foundation	http://dx.doi.org/10.13039/501100000403
CL-2019-16-001	National Institute for Health Research	http://dx.doi.org/10.13039/501100000272
RP-2017-08-ST2-012	National Institute for Health Research	http://dx.doi.org/10.13039/501100000272
R01AI118511	National Institutes of Health	http://dx.doi.org/10.13039/100000002