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(2021)
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
iScience, 24 (11).
p. 103353.
ISSN 2589-0042
https://doi.org/10.1016/j.isci.2021.103353
SGUL Authors: Laing, Kenneth
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Abstract
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.
| Item Type: | Article | |||||||||||||||||||||||||||
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| Additional Information: | © 2021 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||||||||||||||||||||
| Journal or Publication Title: | iScience | |||||||||||||||||||||||||||
| ISSN: | 2589-0042 | |||||||||||||||||||||||||||
| Language: | en | |||||||||||||||||||||||||||
| Dates: |
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| Publisher License: | Creative Commons: Attribution 4.0 | |||||||||||||||||||||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/113853 | |||||||||||||||||||||||||||
| Publisher's version: | https://doi.org/10.1016/j.isci.2021.103353 |
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