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Effectiveness of offering tailored text message, self-help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial and meta-analysis

Coleman, T; Clark, M; Welch, C; Whitemore, R; Leonardi-Bee, J; Cooper, S; Hewitt, C; Jones, M; Sutton, S; Watson, J; et al. Coleman, T; Clark, M; Welch, C; Whitemore, R; Leonardi-Bee, J; Cooper, S; Hewitt, C; Jones, M; Sutton, S; Watson, J; Daykin, K; Ussher, M; Parrott, S; Naughton, F (2022) Effectiveness of offering tailored text message, self-help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial and meta-analysis. Addiction, 117 (4). pp. 1079-1094. ISSN 1360-0443 https://doi.org/10.1111/add.15715
SGUL Authors: Ussher, Michael Henry

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Abstract

AIMS: To test efficacy of "MiQuit', a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy. DESIGN: Multicentre, open, two-arm, parallel-group, superiority randomised controlled trial (RCT) and a Trial Sequential Analysis (TSA) meta-analysis combining trial findings with two previous ones. SETTING: 24 English hospital antenatal clinics. PARTICIPANTS: 1002 pregnant women who were ≥16 years old, were ≤ 25 weeks gestation, and smoked ≥ one daily cigarette and accepted information on cessation with no requirement to set quit dates. INTERVENTIONS: UC or UC plus 'MiQuit': 12 weeks of tailored, smoking cessation text messages focussed on inducing and aiding cessation. MEASUREMENTS: Primary outcome: biochemically-validated cessation between 4 weeks after randomisation and late pregnancy. SECONDARY OUTCOMES: shorter and non-validated abstinence periods, pregnancy outcomes and incremental cost-effectiveness ratios. FINDINGS: RCT: cessation was 5.19% (26/501) and 4.59% (23/501) in MiQuit and UC groups [adjusted odds ratio (adj OR) for quitting with MiQuit versus UC, 95% confidence interval (CI), 1.15 (0.65 to 2.04)]; other abstinence findings were similar, with higher point estimates. Primary outcome ascertainment was 61.7% (309) and 67.3% (337) in MiQuit and UC groups with 71.1% (54/76) and 69.5% (41/59) abstinence validation rates, respectively. Pregnancy outcomes were similar and the incremental cost per Quality-Adjusted Life Year was -£1,118 (95% CI -£4,806 to £1,911). More MiQuit group women reported making at least one quit attempt (adj OR (95% CI) for making an attempt, 1.50 (1.07 to 2.09).TSA Meta-analysis: This found no significant difference in prolonged abstinence between MiQuit and UC (pooled OR 1.49, adjusted 95% CI 0.62 to 3.60). CONCLUSIONS: Irrespective of whether they want to try quitting, when offered a tailored, self-help, text message stop smoking programme for pregnancy (MiQuit) as an adjunct to usual care, pregnant women are not more likely to stop smoking until childbirth but they report more attempts at stopping smoking.

Item Type: Article
Additional Information: © 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, Substance Abuse
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Addiction
ISSN: 1360-0443
Language: eng
Dates:
DateEvent
8 March 2022Published
5 November 2021Published Online
22 September 2021Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
RP-PG-0109-10020National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
C11232/A23434Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
PubMed ID: 34636086
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/113741
Publisher's version: https://doi.org/10.1111/add.15715

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