Molloy, SF;
Ross, B;
Kanyama, C;
Mfinanga, S;
Lesikari, S;
Heyderman, RS;
Kalata, N;
Ellis, J;
Kouanfack, C;
Chanda, D;
et al.
Molloy, SF; Ross, B; Kanyama, C; Mfinanga, S; Lesikari, S; Heyderman, RS; Kalata, N; Ellis, J; Kouanfack, C; Chanda, D; Temfack, E; Lakhi, S; Moodley, A; Chan, AK; van Oosterhout, JJ; Mapoure, Y; Mwaba, P; Lalloo, DG; Wang, D; Lortholary, O; Jaffar, S; Hosseinipour, MC; Loyse, A; Harrison, TS; Bicanic, T
(2021)
Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.
Open Forum Infect Dis, 8 (4).
ofab066.
ISSN 2328-8957
https://doi.org/10.1093/ofid/ofab066
SGUL Authors: Bicanic, Tihana
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Abstract
Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36-4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58-5.7; P = .003) were independently associated with severe visual loss.
| Item Type: | Article | |||||||||
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| Additional Information: | © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||
| Keywords: | HIV, cryptococcal meningitis, fungal burden, raised intracranial pressure, visual loss | |||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Infection and Immunity Research Institute (INII) | |||||||||
| Journal or Publication Title: | Open Forum Infect Dis | |||||||||
| ISSN: | 2328-8957 | |||||||||
| Language: | eng | |||||||||
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| Publisher License: | Creative Commons: Attribution 4.0 | |||||||||
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| PubMed ID: | 33937434 | |||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/113263 | |||||||||
| Publisher's version: | https://doi.org/10.1093/ofid/ofab066 |
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