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Coffee consumption and risk of breast cancer: A Mendelian randomization study.

Ellingjord-Dale, M; Papadimitriou, N; Katsoulis, M; Yee, C; Dimou, N; Gill, D; Aune, D; Ong, J-S; MacGregor, S; Elsworth, B; et al. Ellingjord-Dale, M; Papadimitriou, N; Katsoulis, M; Yee, C; Dimou, N; Gill, D; Aune, D; Ong, J-S; MacGregor, S; Elsworth, B; Lewis, SJ; Martin, RM; Riboli, E; Tsilidis, KK (2021) Coffee consumption and risk of breast cancer: A Mendelian randomization study. PLoS One, 16 (1). ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0236904
SGUL Authors: Gill, Dipender Preet Singh

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Abstract

BACKGROUND: Observational studies have reported either null or weak protective associations for coffee consumption and risk of breast cancer. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between coffee consumption and breast cancer risk using 33 single-nucleotide polymorphisms (SNPs) associated with coffee consumption from a genome-wide association (GWA) study on 212,119 female UK Biobank participants of White British ancestry. Risk estimates for breast cancer were retrieved from publicly available GWA summary statistics from the Breast Cancer Association Consortium (BCAC) on 122,977 cases (of which 69,501 were estrogen receptor (ER)-positive, 21,468 ER-negative) and 105,974 controls of European ancestry. Random-effects inverse variance weighted (IVW) MR analyses were performed along with several sensitivity analyses to assess the impact of potential MR assumption violations. RESULTS: One cup per day increase in genetically predicted coffee consumption in women was not associated with risk of total (IVW random-effects; odds ratio (OR): 0.91, 95% confidence intervals (CI): 0.80-1.02, P: 0.12, P for instrument heterogeneity: 7.17e-13), ER-positive (OR = 0.90, 95% CI: 0.79-1.02, P: 0.09) and ER-negative breast cancer (OR: 0.88, 95% CI: 0.75-1.03, P: 0.12). Null associations were also found in the sensitivity analyses using MR-Egger (total breast cancer; OR: 1.00, 95% CI: 0.80-1.25), weighted median (OR: 0.97, 95% CI: 0.89-1.05) and weighted mode (OR: 1.00, CI: 0.93-1.07). CONCLUSIONS: The results of this large MR study do not support an association of genetically predicted coffee consumption on breast cancer risk, but we cannot rule out existence of a weak association.

Item Type: Article
Additional Information: Copyright: © 2021 Ellingjord-Dale et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: MD Multidisciplinary, General Science & Technology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLoS One
Article Number: e0236904
ISSN: 1932-6203
Language: eng
Dates:
DateEvent
19 January 2021Published
3 January 2021Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
WCRF 2014/1180World Cancer Research Fundhttp://dx.doi.org/10.13039/501100000321
C18281/A19169Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
MC_UU_12013/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12013/2Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MC_UU_12013/3Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 33465101
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112856
Publisher's version: https://doi.org/10.1371/journal.pone.0236904

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