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Extensive mucocutaneous, oesophageal and otic lichen planus secondary to nivolumab therapy

Ferguson, L; Ho, B; Weir, J; Francis, N; West, K; Rathbone, B; Larkin, J; Heelan, K (2021) Extensive mucocutaneous, oesophageal and otic lichen planus secondary to nivolumab therapy. Skin Health and Disease, 1 (1). e8. ISSN 2690-442X https://doi.org/10.1002/ski2.8
SGUL Authors: Ho, Bernard Chi-Lok

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Abstract

We report a 73‐year‐old female with metastatic renal cell carcinoma who developed a widespread lichenoid reaction following nivolumab treatment. The timeline of the reaction strongly correlated with the nivolumab treatment and subsequent cessation. Our patient had cutaneous, mucosal, otic, ophthalmic and oesophageal involvement, demonstrating the potentially extensive nature of lichenoid reactions to anti‐programmed cell death receptor‐1 (anti‐PD1) therapies. Although lichenoid reactions to anti‐PD1 therapies are now well recognized, there have been no previous reports of otic or oesophageal involvement in the literature. Although cutaneous lichenoid reactions do not tend to be severe or treatment limiting, more widespread systemic lichenoid reactions are challenging to manage, particularly in the context of malignancy. This very unusual case highlights the importance of considering involvement beyond the skin in all lichenoid skin reactions.

Item Type: Article
Additional Information: © 2020 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Skin Health and Disease
ISSN: 2690-442X
Language: en
Dates:
DateEvent
7 March 2021Published
20 November 2020Published Online
23 October 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
URI: https://openaccess.sgul.ac.uk/id/eprint/112625
Publisher's version: https://doi.org/10.1002/ski2.8

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