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Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis

Fletcher, PD; Downey, LE; Golden, HL; Clark, CN; Slattery, CF; Paterson, RW; Schott, JM; Rohrer, JD; Rossor, MN; Warren, JD (2015) Auditory hedonic phenotypes in dementia: A behavioural and neuroanatomical analysis. Cortex, 67. pp. 95-105. ISSN 0010-9452
SGUL Authors: Clark, Camilla Neegaard

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Patients with dementia may exhibit abnormally altered liking for environmental sounds and music but such altered auditory hedonic responses have not been studied systematically. Here we addressed this issue in a cohort of 73 patients representing major canonical dementia syndromes (behavioural variant frontotemporal dementia (bvFTD), semantic dementia (SD), progressive nonfluent aphasia (PNFA) amnestic Alzheimer's disease (AD)) using a semi-structured caregiver behavioural questionnaire and voxel-based morphometry (VBM) of patients' brain MR images. Behavioural responses signalling abnormal aversion to environmental sounds, aversion to music or heightened pleasure in music (‘musicophilia’) occurred in around half of the cohort but showed clear syndromic and genetic segregation, occurring in most patients with bvFTD but infrequently in PNFA and more commonly in association with MAPT than C9orf72 mutations. Aversion to sounds was the exclusive auditory phenotype in AD whereas more complex phenotypes including musicophilia were common in bvFTD and SD. Auditory hedonic alterations correlated with grey matter loss in a common, distributed, right-lateralised network including antero-mesial temporal lobe, insula, anterior cingulate and nucleus accumbens. Our findings suggest that abnormalities of auditory hedonic processing are a significant issue in common dementias. Sounds may constitute a novel probe of brain mechanisms for emotional salience coding that are targeted by neurodegenerative disease.

Item Type: Article
Additional Information: © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (
Keywords: 1109 Neurosciences, 1702 Cognitive Sciences, Experimental Psychology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Cortex
ISSN: 0010-9452
Language: en
June 2015Published
8 April 2015Published Online
27 March 2015Accepted
Publisher License: Creative Commons: Attribution 4.0
Project IDFunderFunder ID
MR/J011274/1Medical Research Council
ART-PhD2011-10Alzheimer Research UKUNSPECIFIED
091673/Z/10/ZWellcome Trust
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