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Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status

Killick, E; Tymrakiewicz, M; Cieza-Borrella, C; Smith, P; Thompson, DJ; Pooley, KA; Easton, DF; Bancroft, E; Page, E; Leongamornlert, D; et al. Killick, E; Tymrakiewicz, M; Cieza-Borrella, C; Smith, P; Thompson, DJ; Pooley, KA; Easton, DF; Bancroft, E; Page, E; Leongamornlert, D; Kote-Jarai, Z; Eeles, RA (2014) Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status. PLoS ONE, 9 (1). e86659-e86659. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0086659
SGUL Authors: Cieza-Borrella, Clara Isabel

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Abstract

This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrolment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrolment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linear regression analyses were used to assess whether TL was associated with BRCA1/2 mutation status or cancer risk. We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. It is the first study investigating TL in a cohort of genetically predisposed males and although TL and BRCA status was previously studied in females our results don't support the previous finding of association between hereditary breast cancer and shorter TL.

Item Type: Article
Additional Information: Copyright: © 2014 Killick et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: MD Multidisciplinary, General Science & Technology
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: PLoS ONE
ISSN: 1932-6203
Language: en
Dates:
DateEvent
29 January 2014Published
11 December 2013Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
C5047/A13232Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C5047/A15007Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
URI: https://openaccess.sgul.ac.uk/id/eprint/111866
Publisher's version: https://doi.org/10.1371/journal.pone.0086659

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