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Physiological phenotyping of dementias using emotional sounds.

Fletcher, PD; Nicholas, JM; Shakespeare, TJ; Downey, LE; Golden, HL; Agustus, JL; Clark, CN; Mummery, CJ; Schott, JM; Crutch, SJ; et al. Fletcher, PD; Nicholas, JM; Shakespeare, TJ; Downey, LE; Golden, HL; Agustus, JL; Clark, CN; Mummery, CJ; Schott, JM; Crutch, SJ; Warren, JD (2015) Physiological phenotyping of dementias using emotional sounds. Alzheimers Dement (Amst), 1 (2). pp. 170-178. ISSN 2352-8729 https://doi.org/10.1016/j.dadm.2015.02.003
SGUL Authors: Clark, Camilla Neegaard

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Abstract

INTRODUCTION: Emotional behavioral disturbances are hallmarks of many dementias but their pathophysiology is poorly understood. Here we addressed this issue using the paradigm of emotionally salient sounds. METHODS: Pupil responses and affective valence ratings for nonverbal sounds of varying emotional salience were assessed in patients with behavioral variant frontotemporal dementia (bvFTD) (n = 14), semantic dementia (SD) (n = 10), progressive nonfluent aphasia (PNFA) (n = 12), and AD (n = 10) versus healthy age-matched individuals (n = 26). RESULTS: Referenced to healthy individuals, overall autonomic reactivity to sound was normal in Alzheimer's disease (AD) but reduced in other syndromes. Patients with bvFTD, SD, and AD showed altered coupling between pupillary and affective behavioral responses to emotionally salient sounds. DISCUSSION: Emotional sounds are a useful model system for analyzing how dementias affect the processing of salient environmental signals, with implications for defining pathophysiological mechanisms and novel biomarker development.

Item Type: Article
Additional Information: © 2015 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Alzheimer's disease, Autonomic, Emotion, Frontotemporal dementia, Pupillometry, Sound
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Alzheimers Dement (Amst)
ISSN: 2352-8729
Language: eng
Dates:
DateEvent
June 2015Published
22 April 2015Published Online
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
091673Wellcome Trusthttp://dx.doi.org/10.13039/100004440
CBRC 161National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
MR/J011274/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
ART-PhD2011-10Alzheimer Research UKUNSPECIFIED
ART-SRF2010-3Alzheimer Research UKUNSPECIFIED
PubMed ID: 26634223
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111496
Publisher's version: https://doi.org/10.1016/j.dadm.2015.02.003

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