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CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention.

Yan, Y; Chen, R; Wang, X; Hu, K; Huang, L; Lu, M; Hu, Q (2019) CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention. Front Cell Dev Biol, 7. p. 212. ISSN 2296-634X https://doi.org/10.3389/fcell.2019.00212
SGUL Authors: Hu, Qinxue

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Abstract

Chemokine (C-C motif) ligand 19 (CCL19) is a critical regulator of the induction of T cell activation, immune tolerance, and inflammatory responses during continuous immune surveillance, homeostasis, and development. Migration of CC-chemokine receptor 7 (CCR7)-expressing cells to secondary lymphoid organs is a crucial step in the onset of adaptive immunity, which is initiated by a complex interaction between CCR7 and its cognate ligands. Recent advances in knowledge regarding the response of the CCL19-CCR7 axis to viral infections have elucidated the complex network of interplay among the invading virus, target cells and host immune responses. Viruses use various strategies to evade or delay the cytokine response, gaining additional time to replicate in the host. In this review, we summarize the impacts of CCL19 and CCR7 expression on the regulation of viral pathogenesis with an emphasis on the corresponding signaling pathways and adjuvant mechanisms. We present and discuss the expression, signaling adaptor proteins and effects of CCL19 and CCR7 as these molecules differentially impact different viral infections and viral life cycles in host homeostatic strategies. The underlying mechanisms discussed in this review may assist in the design of novel agents to modulate chemokine activity for viral prevention.

Item Type: Article
Additional Information: © 2019 Yan, Chen, Wang, Hu, Huang, Lu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: CCL19, CCR7, adjuvant, antivirus, chemotaxis, signaling
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Front Cell Dev Biol
ISSN: 2296-634X
Language: eng
Dates:
DateEvent
1 October 2019Published
18 September 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
CSE31N1607Wuxi Technology Bureau Scientific and Technology ProjectUNSPECIFIED
2015NJMUZD078Nanjing Medical University ProjectUNSPECIFIED
ZDRC024Wuxi Key Medical Talents ProgrammeUNSPECIFIED
MS201702Wuxi Health and Family Planning CommissionUNSPECIFIED
81701550National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
81572009National Natural Science Foundation of Chinahttp://dx.doi.org/10.13039/501100001809
2019IOV005State Key Laboratory of VirologyUNSPECIFIED
RTG1949Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
Transregio TRR60Deutsche Forschungsgemeinschafthttp://dx.doi.org/10.13039/501100001659
PubMed ID: 31632965
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111378
Publisher's version: https://doi.org/10.3389/fcell.2019.00212

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