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Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS.

Smith, SP; Wu, G; Fooks, AR; Ma, J; Banyard, AC (2019) Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS. J Gen Virol, 100 (8). pp. 1171-1186. ISSN 1465-2099 https://doi.org/10.1099/jgv.0.001269
SGUL Authors: Ma, Julian

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Abstract

Rabies virus causes an invariably fatal encephalitis following the onset of clinical disease. Despite the availability of safe and effective vaccines, the clinical stages of rabies encephalitis remain untreatable, with few survivors being documented. A principal obstacle to the treatment of rabies is the neurotropic nature of the virus, with the blood-brain barrier size exclusion limit rendering the delivery of antiviral drugs and molecules to the central nervous system inherently problematic. This review focuses on efforts to try and overcome barriers to molecule delivery to treat clinical rabies and overviews current progress in the development of experimental live rabies virus vaccines that may have future applications in the treatment of clinical rabies, including the attenuation of rabies virus vectors through either the duplication or mutation of existing genes or the incorporation of non-viral elements within the genome. Rabies post-infection treatment (PIT) remains the holy grail of rabies research.

Item Type: Article
Additional Information: © the Author(s), 2019. The definitive peer reviewed, edited version of this article is published in Journal of General Virology, volume 100, issue 8, 2019, DOI: 10.1099/jgv.0.001269.
Keywords: clinical, disease, post-exposure prophylaxis (PEP), post-infection treatment (PIT), rabies, 06 Biological Sciences, 07 Agricultural And Veterinary Sciences, 11 Medical And Health Sciences, Virology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Gen Virol
ISSN: 1465-2099
Language: eng
Dates:
DateEvent
August 2019Published
1 August 2019Published Online
13 April 2019Accepted
PubMed ID: 31237530
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111373
Publisher's version: https://doi.org/10.1099/jgv.0.001269

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