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Current Practices in Ileal Pouch Surveillance for Patients With Ulcerative Colitis: A Multinational, Retrospective Cohort Study.

Samaan, MA; Forsyth, K; Segal, JP; De Jong, D; Vleugels, JLA; Elkady, S; Kabir, M; Campbell, S; Kok, K; Armstrong, DG; et al. Samaan, MA; Forsyth, K; Segal, JP; De Jong, D; Vleugels, JLA; Elkady, S; Kabir, M; Campbell, S; Kok, K; Armstrong, DG; Penez, L; Arenaza, AP; Seward, E; Vega, R; Mehta, S; Rahman, F; McCartney, S; Bloom, S; Patel, K; Pollok, R; Westcott, E; Darakhshan, A; Williams, A; Koumoutsos, I; Ray, S; Mawdsley, J; Anderson, S; Sanderson, JD; Dekker, E; D'Haens, GR; Hart, A; Irving, PM (2019) Current Practices in Ileal Pouch Surveillance for Patients With Ulcerative Colitis: A Multinational, Retrospective Cohort Study. J Crohns Colitis, 13 (6). pp. 735-743. ISSN 1876-4479 https://doi.org/10.1093/ecco-jcc/jjy225
SGUL Authors: Pollok, Richard Charles G

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Abstract

BACKGROUND AND AIMS: There are no universally accepted guidelines regarding surveillance of ulcerative colitis [UC] patients after restorative proctocolectomy and ileal pouch-anal anastomosis [IPAA]. There also exists a lack of validated quality assurance standards for performing pouchoscopy. To better understand IPAA surveillance practices in the face of this clinical equipoise, we carried out a retrospective cohort study at five inflammatory bowel disease [IBD] referral centres. METHODS: Records of patients who underwent IPAA for UC or IBD unclassified [IBDU] were reviewed, and patients with <1-year follow-up after restoration of intestinal continuity were excluded. Criteria for determining the risk of pouch dysplasia formation were collected as well as the use of pouchoscopy, biopsies, and completeness of reports. RESULTS: We included 272 patients. Median duration of pouch follow-up was 10.5 [3.3-23.6] years; 95/272 [35%] had never undergone pouchoscopy for any indication; 191/272 [70%] had never undergone pouchoscopy with surveillance as the specific indication; and 3/26 [12%] high-risk patients had never undergone pouchoscopy. Two cases of adenocarcinoma were identified, occurring in the rectal cuff of low-risk patients. Patients under the care of surgeons appeared more likely to undergo surveillance, but rates of incomplete reporting were higher among surgeons [78%] than gastroenterologists [54%, p = 0.002]. CONCLUSIONS: We observed wide variation in surveillance of UC/IBDU-IPAA patients. In addition, the rate of neoplasia formation among 'low-risk' patients was higher than may have been expected. We therefore concur with previous recommendations that pouchoscopy be performed at 1 year postoperatively, to refine risk-stratification based on clinical factors alone. Reports should document findings in all regions of the pouch and biopsies should be taken.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Crohn's and Colitis following peer review. The version of record Mark A Samaan, Katrina Forsyth, Jonathan P Segal, Djuna De Jong, Jasper L A Vleugels, Soad Elkady, Misha Kabir, Samantha Campbell, Klaartje Kok, David G Armstrong, Lawrence Penez, Aitor P Arenaza, Edward Seward, Roser Vega, Shameer Mehta, Farooq Rahman, Sara McCartney, Stuart Bloom, Kamal Patel, Richard Pollok, Edward Westcott, Amir Darakhshan, Andrew Williams, Ioannis Koumoutsos, Shuvra Ray, Joel Mawdsley, Simon Anderson, Jeremy D Sanderson, Evelien Dekker, Geert R D’Haens, Ailsa Hart, Peter M Irving, Current Practices in Ileal Pouch Surveillance for Patients With Ulcerative Colitis: A Multinational, Retrospective Cohort Study, Journal of Crohn's and Colitis, Volume 13, Issue 6, June 2019, Pages 735–743 is available online at: https://doi.org/10.1093/ecco-jcc/jjy225
Keywords: Ileal pouch, ileal pouch-anal anastomosis, ileoanal pouch, surveillance, ulcerative colitis, Ileal pouch, ileoanal pouch, ileal pouch-anal anastomosis, surveillance, ulcerative colitis, Gastroenterology & Hepatology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Crohns Colitis
ISSN: 1876-4479
Language: eng
Dates:
DateEvent
27 May 2019Published
24 December 2019Published Online
PubMed ID: 30590513
Web of Science ID: WOS:000469781200007
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111309
Publisher's version: https://doi.org/10.1093/ecco-jcc/jjy225

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