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Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines

Meloni, MM; Barton, S; Chivu, A; Kaski, JC; Song, W; He, T (2018) Facile, productive, and cost-effective synthesis of a novel tetrazine-based iron oxide nanoparticle for targeted image contrast agents and nanomedicines. JOURNAL OF NANOPARTICLE RESEARCH, 20 (10). p. 265. ISSN 1388-0764 https://doi.org/10.1007/s11051-018-4370-8
SGUL Authors: Kaski, Juan Carlos He, Taigang

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Abstract

We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials. Our protocol proceeds at room temperature and uses hexafluorophosphate azabenzotriazole tetramethyl uronium, a well-known, widely used reagent for the large-scale industrial production of important pharmaceuticals. The nanoparticles obtained have a diameter range between 16 and 21 nm and showed no toxicity against endothelial cell lines. The tetrazine moiety on the nanoparticle surface could potentially allow further attachment of specific targeting vectors by using so-called copper-free click chemistry. We therefore anticipate that our protocol can represent a significant breakthrough in the future development and commercialization of improved, tissue-specific contrast agents and drug delivery for clinical diagnosis, monitoring and therapy of diseases at an asymptomatic stage.

Item Type: Article
Additional Information: This is a post-peer-review, pre-copyedit version of an article published in Journal of Nanoparticle Research. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11051-018-4370-8
Keywords: Diagnosis, Magnetic resonance imaging, Iron oxide nanoparticles, Copper-free click chemistry, Bioconjugation, Synthesis, Diagnosis, Magnetic resonance imaging, Iron oxide nanoparticles, Copper-free click chemistry, Bioconjugation, Synthesis, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, 0912 Materials Engineering, 1007 Nanotechnology, Nanoscience & Nanotechnology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: JOURNAL OF NANOPARTICLE RESEARCH
ISSN: 1388-0764
Dates:
DateEvent
October 2018Published
28 September 2018Published Online
19 September 2018Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
FS/15/17/31411British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
Web of Science ID: WOS:000446378700001
URI: https://openaccess.sgul.ac.uk/id/eprint/111287
Publisher's version: https://doi.org/10.1007/s11051-018-4370-8

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