SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Emerging Themes for the Role of Antibodies in Tuberculosis.

Tran, AC; Kim, M-Y; Reljic, R (2019) Emerging Themes for the Role of Antibodies in Tuberculosis. Immune Netw, 19 (4). ISSN 1598-2629 https://doi.org/10.4110/in.2019.19.e24
SGUL Authors: Reljic, Rajko

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (1MB) | Preview

Abstract

The best way to debunk a scientific dogma is to throw irrefutable evidence at it. This is especially true if the dogma in question has been nurtured over many decades, as is the case with the apparent redundancy of antibodies (Abs) against intracellular pathogens. Although not fully compelling yet, that 'hard core' evidence is nevertheless now slowly beginning to emerge. This is true for several clinically relevant infections but none more so than Mycobacterium tuberculosis, the archetype intracellular pathogen that poses a great health challenge to the mankind. Here, prompted by a spate of recent high-profile reports on the effects of Abs in various experimental models of tuberculosis, we step back and take a critical look at the progress that has been made in the last 5 years and highlight some of the strengths and shortcomings of the presented evidence. We conclude that the tide of the opinion has begun to turn in favour of Abs but we also caution against overinterpreting the currently available limited evidence. For, until definitive evidence that can withstand even the most rigorous of experimental tests is produced, the dogma may yet survive. Or indeed, we may find that the truth is hidden somewhere in between the dogma and the unfulfilled scientific prophecy.

Item Type: Article
Additional Information: Copyright © 2019. The Korean Association of Immunologists This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Antibodies, Immunotherapy, Infection, Tuberculosis, Vaccines, Tuberculosis, Antibodies, Vaccines, Immunotherapy, Infection
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Immune Netw
Article Number: e24
ISSN: 1598-2629
Language: eng
Dates:
DateEvent
August 2019Published
13 June 2019Accepted
Publisher License: Creative Commons: Attribution-Noncommercial 4.0
Projects:
Project IDFunderFunder ID
643558Horizon 2020UNSPECIFIED
PubMed ID: 31501712
Web of Science ID: WOS:000484344600002
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111266
Publisher's version: https://doi.org/10.4110/in.2019.19.e24

Statistics

Item downloaded times since 09 Oct 2019.

Actions (login required)

Edit Item Edit Item