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UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence.

Bratcher, HB; Rodrigues, CMC; Finn, A; Wootton, M; Cameron, JC; Smith, A; Heath, P; Ladhani, S; Snape, MD; Pollard, AJ; et al. Bratcher, HB; Rodrigues, CMC; Finn, A; Wootton, M; Cameron, JC; Smith, A; Heath, P; Ladhani, S; Snape, MD; Pollard, AJ; Cunningham, R; Borrow, R; Trotter, C; Gray, SJ; Maiden, MCJ; MacLennan, JM (2019) UKMenCar4: A cross-sectional survey of asymptomatic meningococcal carriage amongst UK adolescents at a period of low invasive meningococcal disease incidence. Wellcome Open Res, 4. p. 118. ISSN 2398-502X https://doi.org/10.12688/wellcomeopenres.15362.2
SGUL Authors: Heath, Paul Trafford Ladhani, Shamez Nizarali

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Abstract

Carriage of Neisseria meningitidis, the meningococcus, is a prerequisite for invasive meningococcal disease (IMD), a potentially devastating infection that disproportionately afflicts infants and children. Humans are the sole known reservoir for the meningococcus, and it is carried asymptomatically in the nasopharynx of ~10% of the population. Rates of carriage are dependent on age of the host and social and behavioural factors. In the UK, meningococcal carriage has been studied through large, multi-centre carriage surveys of adolescents in 1999, 2000, and 2001, demonstrating carriage can be affected by immunisation with the capsular group C meningococcal conjugate vaccine, inducing population immunity against carriage. Fifteen years after these surveys were carried out, invasive meningococcal disease incidence had declined from a peak in 1999.  The UKMenCar4 study was conducted in 2014/15 to investigate rates of carriage amongst the adolescent population during a period of low disease incidence. The protocols and methodology used to perform UKMenCar4, a large carriage survey, are described here.

Item Type: Article
Additional Information: © 2019 Bratcher HB et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Neisseria meningitidis, UKMenCar, adolescent, meningococcal carriage, population genomics, population immunity, Neisseria meningitidis, UKMenCar, adolescent, meningococcal carriage, population genomics, population immunity
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Wellcome Open Res
ISSN: 2398-502X
Language: eng
Dates:
DateEvent
6 August 2019Published
26 July 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
087622Wellcome Trusthttp://dx.doi.org/10.13039/100004440
PR-ST-0915-10015National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
PubMed ID: 31544158
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111228
Publisher's version: https://doi.org/10.12688/wellcomeopenres.15362.2

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