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Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain-the WESTCOR study: study design.

Tjora, HL; Steiro, O-T; Langørgen, J; Bjørneklett, R; Nygård, OK; Renstrøm, R; Skadberg, Ø; Bonarjee, VVS; Lindahl, B; Collinson, P; et al. Tjora, HL; Steiro, O-T; Langørgen, J; Bjørneklett, R; Nygård, OK; Renstrøm, R; Skadberg, Ø; Bonarjee, VVS; Lindahl, B; Collinson, P; Omland, T; Vikenes, K; Aakre, KM (2019) Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain-the WESTCOR study: study design. Scand Cardiovasc J, 53 (5). pp. 280-285. ISSN 1651-2006 https://doi.org/10.1080/14017431.2019.1634280
SGUL Authors: Collinson, Paul

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Abstract

Objectives. The main aim of the Aiming toWards Evidence baSed inTerpretation of Cardiac biOmarkers in patients pResenting with chest pain (WESTCOR-study) (Clinical Trials number NCT02620202) is to improve diagnostic pathways for patients presenting to the Emergency department (ED) with acute chest pain. Design. The WESTCOR-study is a two center, cross-sectional and prospective observational study recruiting unselected patients presenting to the ED with suspected non-ST elevation acute coronary syndrome (NSTE-ACS). Patient inclusion started September 2015 and we plan to include 2250 patients, finishing in 2019. The final diagnosis will be adjudicated by two independent cardiologists based on all available information including serial high sensitivity cardiac troponin measurements, coronary angiography, coronary CT angiography and echocardiography. The study includes one derivation cohort (N = 985) that will be used to develop rule out/rule in algorithms for NSTEMI and NSTE-ACS (if possible) using novel troponin assays, and to validate established NSTEMI algorithms, with and without clinical scoring systems. The study further includes one subcohort (n = 500) where all patients are examined with coronary CT angiography independent of biomarker status, aiming to assess the associations between biomarkers and the extent and severity of coronary atherosclerosis. Finally, an external validation cohort (N = 750) will be included at Stavanger University Hospital. Prospective studies will be based on the merged cohorts. Conclusion. The WESTCOR study will provide new diagnostic algorithms for early inclusion and exclusion of NSTE-ACS and insights in the associations between cardiovascular biomarkers, CT-angiographic findings and short and long-term clinical outcomes.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Scandinavian Cardiovascular Journal on 20/06/19, available online: http://www.tandfonline.com/10.1080/14017431.2019.1634280.
Keywords: Chest pain, NSTEMI, acute coronary syndrome, cardiovascular biomarkers, rule in/rule out algorithms, troponin, unstable angina pectoris, Chest pain, acute coronary syndrome, cardiovascular biomarkers, rule in, rule out algorithms, troponin, NSTEMI, unstable angina pectoris, Chest pain, NSTEMI, acute coronary syndrome, cardiovascular biomarkers, rule in/rule out algorithms, troponin, unstable angina pectoris, 1102 Cardiovascular Medicine And Haematology, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Scand Cardiovasc J
ISSN: 1651-2006
Language: eng
Dates:
DateEvent
1 July 2019Published
20 June 2019Published Online
5 June 2019Accepted
Publisher License: Publisher's own licence
PubMed ID: 31216908
Web of Science ID: WOS:000473989000001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111154
Publisher's version: https://doi.org/10.1080/14017431.2019.1634280

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