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Evaluation After Sudden Death in the Young.

Gray, B; Ackerman, MJ; Semsarian, C; Behr, ER (2019) Evaluation After Sudden Death in the Young. Circ Arrhythm Electrophysiol, 12 (8). e007453. ISSN 1941-3084 https://doi.org/10.1161/CIRCEP.119.007453
SGUL Authors: Behr, Elijah Raphael Gray, Belinda Ruth

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Abstract

Sudden cardiac death is defined as a death occurring usually within an hour of onset of symptoms, arising from an underlying cardiac disease. Sudden cardiac death is a complication of a number of cardiovascular diseases and is often unexpected. In individuals aged <35 years, unexplained sudden cardiac death is the most common presentation. A significant proportion of sudden cardiac death in the young (≤35 years) events may be precipitated by underlying inherited cardiac conditions, including both heritable cardiomyopathies and inherited arrhythmia syndromes (also known as cardiac channelopathies). Tragically, sudden death may be the first manifestation of the disease in a family and, therefore, clinical and genetic evaluation of surviving family members forms a key role in diagnosing the underlying inherited cardiac condition in the family. This is particularly relevant when considering that most inherited cardiac conditions are inherited in an autosomal dominant manner meaning that surviving family members have a 50% chance of inheriting the same disease substrate. This review will outline the underlying causes of sudden cardiac death in the young and outline our universal approach to familial evaluation following a young person's sudden death.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form in Gray, B; Ackerman, MJ; Semsarian, C; Behr, ER (2019) Evaluation After Sudden Death in the Young. Circ Arrhythm Electrophysiol, 12 (8).
Keywords: cardiomyopathies, channelopathies, death, sudden, cardiac, prevalence, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Circ Arrhythm Electrophysiol
ISSN: 1941-3084
Language: eng
Dates:
DateEvent
19 August 2019Published
7 July 2019Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
1122330National Health and Medical Research Councilhttp://dx.doi.org/10.13039/501100000925
1154992National Health and Medical Research Councilhttp://dx.doi.org/10.13039/501100000925
PubMed ID: 31422686
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111144
Publisher's version: https://doi.org/10.1161/CIRCEP.119.007453

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