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Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function.

Ridder, A; Giorgione, V; Khalil, A; Thilaganathan, B (2019) Preeclampsia: The Relationship between Uterine Artery Blood Flow and Trophoblast Function. Int J Mol Sci, 20 (13). ISSN 1422-0067 https://doi.org/10.3390/ijms20133263
SGUL Authors: Thilaganathan, Baskaran Khalil, Asma

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Abstract

Maternal uterine artery blood flow is critical to maintaining the intrauterine environment, permitting normal placental function, and supporting fetal growth. It has long been believed that inadequate transformation of the maternal uterine vasculature is a consequence of primary defective trophoblast invasion and leads to the development of preeclampsia. That early pregnancy maternal uterine artery perfusion is strongly associated with placental cellular function and behaviour has always been interpreted in this context. Consistently observed changes in pre-conceptual maternal and uterine artery blood flow, abdominal pregnancy implantation, and late pregnancy have been challenging this concept, and suggest that abnormal placental perfusion may result in trophoblast impairment, rather than the other way round. This review focuses on evidence that maternal cardiovascular function plays a significant role in the pathophysiology of preeclampsia.

Item Type: Article
Additional Information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: maternal cardiovascular system, preeclampsia, uterine artery, 0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences, Chemical Physics
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Int J Mol Sci
ISSN: 1422-0067
Language: eng
Dates:
DateEvent
2 July 2019Published
28 June 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
765274Horizon 2020UNSPECIFIED
PubMed ID: 31269775
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111036
Publisher's version: https://doi.org/10.3390/ijms20133263

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