SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women.

Osman, MW; Nath, M; Khalil, A; Webb, DR; Robinson, TG; Mousa, HA (2017) Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women. Pregnancy Hypertens, 10. pp. 256-261. ISSN 2210-7797 https://doi.org/10.1016/j.preghy.2017.10.007
SGUL Authors: Khalil, Asma

[img]
Preview
PDF Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (448kB) | Preview

Abstract

AIM: A single-centre, prospective longitudinal study to assess changes in maternal arterial stiffness and cardiac output parameters among low-risk healthy pregnant women. METHODOLOGY: Thirty low-risk, healthy, pregnant women attending their routine antenatal dating ultrasound scan were recruited. Non-invasive assessment of arterial stiffness and cardiac output was undertaken at five gestational windows from 11 to 40 weeks of pregnancy. Data were analysed using a linear mixed model incorporating time and other relevant predictors as fixed effects, and patient as a random effect. RESULTS: Gestational age had a significant effect on all arterial stiffness parameters, including brachial augmentation index (AIx) (p = .001), aortic AIx (p = .002) and aortic pulse wave velocity (p = .002). The aortic AIx (%) reduced during pregnancy: the lowest mean (standard error, SE) was 4.07 (1.01) at 28 weeks before it increased to 7.04 (SE 1.64) at 40 weeks. Similarly, non-invasive assessments of cardiac output (p < .001), stroke volume (p = .014), heart rate (p < .001) and total peripheral resistance (p < .001) demonstrated significant changes with gestational age. Mean cardiac output (l/m) increased during pregnancy reaching a peak at 28 weeks gestation 6.66 (SE 0.28), but dropped thereafter to reach 5.71 (SE 0.25) around term. CONCLUSION: The current study provides pregnancy normograms for gestational changes in arterial stiffness and cardiac output parameters among low-risk, healthy pregnant women. Further work will be required to assess the risk of placental mediated diseases and pregnancy outcome among pregnant women with parameters outside the normal range.

Item Type: Article
Additional Information: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Arterial stiffness, Maternal haemodynamics, Non-invasive cardiac output monitoring, Pregnancy, Adult, Aorta, Cardiac Output, Female, Humans, Longitudinal Studies, Pregnancy, Pregnancy Trimesters, Prospective Studies, Reference Values, Vascular Stiffness, Aorta, Humans, Cardiac Output, Longitudinal Studies, Prospective Studies, Pregnancy, Pregnancy Trimesters, Reference Values, Adult, Female, Vascular Stiffness, Maternal haemodynamics, Arterial stiffness, Non-invasive cardiac output monitoring, Pregnancy, Arterial stiffness, Maternal haemodynamics, Non-invasive cardiac output monitoring, Pregnancy
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Pregnancy Hypertens
ISSN: 2210-7797
Language: eng
Dates:
DateEvent
October 2017Published
16 October 2017Published Online
14 October 2017Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 29089251
Web of Science ID: WOS:000415611600047
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110971
Publisher's version: https://doi.org/10.1016/j.preghy.2017.10.007

Actions (login required)

Edit Item Edit Item