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Diagnosis of ruptured abdominal aortic aneurysm: a multicentre cohort study.

Metcalfe, D; Sugand, K; Thrumurthy, SG; Thompson, MM; Holt, PJ; Karthikesalingam, AP (2016) Diagnosis of ruptured abdominal aortic aneurysm: a multicentre cohort study. Eur J Emerg Med, 23 (5). pp. 386-390. ISSN 1473-5695 https://doi.org/10.1097/MEJ.0000000000000281
SGUL Authors: Holt, Peter James Edward Thompson, Matthew Merfyn Karthikesalingam, Alan Prasana

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Abstract

OBJECTIVE: The aim of this study was to describe the presentation of patients with ruptured abdominal aortic aneurysm (rAAA) and identify factors contributing toward misdiagnosis. METHODS: This was an observational study of cases with a final diagnosis of rAAA assessed at nine Emergency Departments and managed at one of two regional vascular centres in the UK. RESULTS: Eighty-five consecutive cases were included. Seventeen [20.0%, 95% confidence interval (CI) 11.5-28.5%] patients reported important symptoms up to 3 weeks before index presentation. In the Emergency Department, most patients complained of abdominal and/or back pain, seven (8.2%, 95% CI 2.4-14.0%) additionally reported atypical pain and ten (11.8%, 95% CI 4.9-18.7%) denied pain altogether. Hypotension (36.5%, 95% CI 26.3-46.7%), tachycardia (18.8%, 95% CI 10.5-27.1%) and syncope (36.5%, 95% CI 26.3-46.7%) were documented in a minority of cases. Distracting symptoms were present in 33 (38.8%, 95% CI 28.4-49.2%) patients. The median time to diagnosis was 17.5 min (range immediate-12 days), and 21 (25.6%, 95% CI 16.3-34.9%) patients were misdiagnosed during clinical assessment. CONCLUSION: The classical signs and symptoms or rAAA are not always present and patients frequently show additional features that may confound the diagnosis. A high level of suspicion should be adopted for rAAA alongside a low threshold for immediate computed tomography. Further research is required to develop an objective clinical risk score or predictive tool for characterizing patients at risk.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form in Metcalfe, D; Sugand, K; Thrumurthy, SG; Thompson, MM; Holt, PJ; Karthikesalingam, AP (2016) Diagnosis of ruptured abdominal aortic aneurysm: a multicentre cohort study. Eur J Emerg Med, 23 (5). pp. 386-390.
Keywords: Abdominal Pain, Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, Aortic Rupture, Back Pain, Emergency Service, Hospital, Female, Humans, Hypotension, Male, Middle Aged, Syncope, Tachycardia, Time Factors, United Kingdom, Humans, Syncope, Back Pain, Tachycardia, Aortic Rupture, Aortic Aneurysm, Abdominal, Hypotension, Abdominal Pain, Time Factors, Aged, Aged, 80 and over, Middle Aged, Emergency Service, Hospital, Female, Male, United Kingdom, abdominal aortic aneurysm, delayed diagnosis, ruptured aortic aneurysms, 1103 Clinical Sciences, Emergency & Critical Care Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Vascular & Cardiac Surgery (INCCVC)
Journal or Publication Title: Eur J Emerg Med
ISSN: 1473-5695
Language: eng
Dates:
DateEvent
October 2016Published
9 April 2015Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
NIHR-CS-011-008Department of HealthUNSPECIFIED
PubMed ID: 25969344
Web of Science ID: WOS:000384454300012
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110958
Publisher's version: https://doi.org/10.1097/MEJ.0000000000000281

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