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Developments in depression in epilepsy: screening, diagnosis, and treatment.

Mula, M (2019) Developments in depression in epilepsy: screening, diagnosis, and treatment. Expert Rev Neurother, 19 (3). pp. 269-276. ISSN 1744-8360 https://doi.org/10.1080/14737175.2019.1585244
SGUL Authors: Mula, Marco

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Abstract

INTRODUCTION: Depression is one of the most frequent comorbidities in epilepsy affecting between 17% and 22% of patients, but it is still underdiagnosed and undertreated. Areas covered: This paper discusses recent advances about screening, diagnosis, and treatment of depression in epilepsy taking into account the heterogeneity of clinical scenarios where depression can occur. Expert opinion: A number of screening instruments are now validated for adults with epilepsy, and their psychometric properties are discussed but the NDDI-E is the most practical and cost-effective. Challenges in diagnosing depression in epilepsy are discussed including reasons for the atypical features of mood disorders in epilepsy. Psychological treatments and/or SSRIs are indicated, but the level of evidence is still low. Even if there is no reason to hypothesise that internationally accepted guidelines of treatment of depression outside epilepsy may not be valid, rigorous studies are needed in order to have proper outcome measures. Epilepsy centers should have well-defined care pathways for depression in order to provide access to mental health support when needed.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Neurotherapeutics on 20/02/19 available online: http://www.tandfonline.com/
Keywords: BDI, Epilepsy, NDDI-E, antidepressant drugs, antiepileptic drugs, depression, diagnosis, interictal dysphoric disorder, screening, treatment, Epilepsy, depression, antiepileptic drugs, interictal dysphoric disorder, NDDI-E, BDI, screening, diagnosis, treatment, antidepressant drugs, BDI, Epilepsy, NDDI-E, antidepressant drugs, antiepileptic drugs, depression, diagnosis, interictal dysphoric disorder, screening, treatment, 1109 Neurosciences, 1115 Pharmacology And Pharmaceutical Sciences, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Expert Rev Neurother
ISSN: 1744-8360
Language: eng
Dates:
DateEvent
1 March 2019Published
20 February 2019Published Online
18 February 2019Accepted
Publisher License: Publisher's own licence
PubMed ID: 30784331
Web of Science ID: WOS:000461468200007
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110844
Publisher's version: https://doi.org/10.1080/14737175.2019.1585244

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