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Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010-2017.

Adler, H; Nikolaou, E; Gould, K; Hinds, J; Collins, AM; Connor, V; Hales, C; Hill, H; Hyder-Wright, AD; Zaidi, SR; et al. Adler, H; Nikolaou, E; Gould, K; Hinds, J; Collins, AM; Connor, V; Hales, C; Hill, H; Hyder-Wright, AD; Zaidi, SR; German, EL; Gritzfeld, JF; Mitsi, E; Pojar, S; Gordon, SB; Roberts, AP; Rylance, J; Ferreira, DM (2019) Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010-2017. J Infect Dis, 219 (12). pp. 1989-1993. ISSN 1537-6613 https://doi.org/10.1093/infdis/jiz034
SGUL Authors: Hinds, Jason

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Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

Item Type: Article
Additional Information: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: 11 Medical And Health Sciences, 06 Biological Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Infect Dis
ISSN: 1537-6613
Language: eng
Dates:
DateEvent
15 June 2019Published
28 January 2019Published Online
21 January 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
MR/M011569/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 30690468
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110801
Publisher's version: https://doi.org/10.1093/infdis/jiz034

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