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Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis.

López, JW; Loader, M-CI; Smith, D; Pastorius, D; Bravard, M; Caviedes, L; Romero, KM; Clark, T; Checkley, W; Ticona, E; et al. López, JW; Loader, M-CI; Smith, D; Pastorius, D; Bravard, M; Caviedes, L; Romero, KM; Clark, T; Checkley, W; Ticona, E; Friedland, JS; Gilman, RH (2018) Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis. Am J Trop Med Hyg, 98 (6). pp. 1637-1639. ISSN 1476-1645 https://doi.org/10.4269/ajtmh.17-0425
SGUL Authors: Friedland, Jonathan Samuel

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Abstract

To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60). Taking this and previous evidence together, we conclude FeNO is not of value in either the diagnosis of pulmonary TB or as a marker of treatment response.

Item Type: Article
Additional Information: © The American Society of Tropical Medicine and Hygiene [open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, Tropical Medicine, ALVEOLAR MACROPHAGES, ASTHMA, FRACTION, DISEASE, 11 Medical And Health Sciences, Tropical Medicine
Journal or Publication Title: Am J Trop Med Hyg
ISSN: 1476-1645
Language: eng
Dates:
DateEvent
June 2018Published
26 February 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
R24 TW007988Vanderbilt Universityhttp://dx.doi.org/10.13039/100006537
UNSPECIFIEDUniversity of North CarolinaUNSPECIFIED
UNSPECIFIEDGates Challenge GrantUNSPECIFIED
UNSPECIFIEDNational Institutes of Healthhttp://dx.doi.org/10.13039/100000002
PubMed ID: 29714162
Web of Science ID: WOS:000437095000018
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110637
Publisher's version: https://doi.org/10.4269/ajtmh.17-0425

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